226901-50-4Relevant academic research and scientific papers
Identification of N -[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1 H -indol-1-yl)acetyl]- l -leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2
Thomas, James B.,Giddings, Angela M.,Wiethe, Robert W.,Olepu, Srinivas,Warner, Keith R.,Sarret, Philippe,Gendron, Louis,Longpre, Jean-Michel,Zhang, Yanan,Runyon, Scott P.,Gilmour, Brian P.
, p. 7472 - 7477 (2015/01/08)
Compounds acting via the neurotensin receptor type 2 (NTS2) are known to be active in animal models of acute and chronic pain. To identify novel NTS2 selective analgesics, we searched for NTS2 selective nonpeptide compounds using a FLIPR assay and identif
Substituted indoles and methods of their use
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Page/Page column 20, (2010/11/25)
The present invention relates generally to substituted indoles and methods of using them.
Nitroazole universal bases in peptide nucleic acids
Challa, Hemavathi,Styers, Melanie L.,Woski, Stephen A.
, p. 1639 - 1641 (2008/02/09)
(matrix presented). The syntheses of PNA oligomers containing potential ambiguous nucleobase analogues, namely 3-nitropyrrole and 5-nitroindole, have been accomplished. Hybridization properties of these PNAs with complementary oligodeoxynucleotides were evaluated by thermal denaturation experiments. Both novel residues exhibited little variation in Tm (≤1.5°C) when positioned against any of the four nucleoside bases. The capability to incorporate degenerate sites should further expand the utility of PNA in applications where precise sequence information is not available.
