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(R)-Benzyl 4-hydroxypent-2-ynoate is a benzyl ester derivative featuring a hydroxyl group and an alkyne functional group on the pent-2-ynoate moiety. The (R)-configuration denotes a specific orientation around the chiral center, affecting its reactivity and biological activity. This unique structure and the presence of functional groups render it a valuable intermediate in the synthesis of various chemical compounds, particularly pharmaceuticals and agrochemicals.

226915-53-3

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226915-53-3 Usage

Uses

Used in Pharmaceutical Industry:
(R)-Benzyl 4-hydroxypent-2-ynoate is used as a versatile building block for the synthesis of various pharmaceuticals. Its unique structure and functional groups enable the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
(R)-Benzyl 4-hydroxypent-2-ynoate is used as a key intermediate in the production of agrochemicals. Its specific orientation and functional groups contribute to the creation of effective compounds for agricultural applications, such as pesticides and herbicides.
Used in Organic Synthesis:
(R)-Benzyl 4-hydroxypent-2-ynoate is utilized as a valuable intermediate in organic synthesis. Its hydroxyl and alkyne functional groups allow for further chemical reactions and modifications, leading to the formation of a wide range of chemical compounds with diverse applications.

Check Digit Verification of cas no

The CAS Registry Mumber 226915-53-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,9,1 and 5 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 226915-53:
(8*2)+(7*2)+(6*6)+(5*9)+(4*1)+(3*5)+(2*5)+(1*3)=143
143 % 10 = 3
So 226915-53-3 is a valid CAS Registry Number.

226915-53-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-4-hydroxypentyl-2-ynoic acid benzyl ester

1.2 Other means of identification

Product number -
Other names (2R)-4-hydroxypent-2-ynoic acid benzyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:226915-53-3 SDS

226915-53-3Upstream product

226915-53-3Relevant academic research and scientific papers

Improved large-scale synthesis of(R)-benzyl 4-hydroxyl-2-pentynoate from (R)-3-butyn-2-ol

Fu, Xiaoyong,Yin, Jianguo,Thiruvengadam,McAllister, Timothy L.,Tann, Chou-Hong,Colon, Cesar

, p. 308 - 310 (2002)

A reliable one-pot process for the title compound has been developed for large-scale productions. The effect of reaction conditions such as temperature, order of addition, and amount of the lithiation reagent has been extensively investigated, giving rise to an optimal process with highest attainable yield.

Thrombin Receptor Antagonists Based On The Modified Tricyclic Unit Of Himbacine

-

Page/Page column 34-35, (2008/06/13)

Multiple stereoisomers of the heterocyclic-substituted tricyclics of the formula: or a pharmaceutically acceptable salt, solvate, or ester of said compound wherein R and the stereochemistry are illustrated in the structural formulas herein are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

Metabolism-based identification of a potent thrombin receptor antagonist

Clasby, Martin C.,Chackalamannil, Samuel,Czarniecki, Michael,Doller, Dario,Eagen, Keith,Greenlee, William,Kao, Grace,Lin, Yan,Tsai, Hsingan,Xia, Yan,Ahn, Ho-Sam,Agans-Fantuzzi, Jacqueline,Boykow, George,Chintala, Madhu,Foster, Carolyn,Smith-Torhan, April,Alton, Kevin,Bryant, Matthew,Hsieh, Yunsheng,Lau, Janice,Palamanda, Jairam

, p. 129 - 138 (2008/02/03)

The metabolism of our prototypical thrombin receptor antagonist 1, K i = 2.7 nM, was studied and three major metabolites (2, 4, and 5) were found. The structures of the metabolites were verified independently by synthesis. Compound 4 was shown

Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents

Chackalamannil, Samuel,Xia, Yan,Greenlee, William J.,Clasby, Martin,Doller, Darìo,Tsai, Hsingan,Asberom, Theodros,Czarniecki, Michael,Ahn, Ho-Sam,Boykow, George,Foster, Carolyn,Agans-Fantuzzi, Jacqueline,Bryant, Matthew,Lau, Janice,Chintala, Madhu

, p. 5884 - 5887 (2007/10/03)

Structurally novel thrombin receptor (protease activated receptor 1, PAR-1) antagonists based on the natural product himbacine are described. The prototypical PAR-1 antagonist 55 showed a Ki of 2.7 nM in the binding assay, making it the most po

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