226915-55-5Relevant articles and documents
Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
Chackalamannil, Samuel,Xia, Yan,Greenlee, William J.,Clasby, Martin,Doller, Darìo,Tsai, Hsingan,Asberom, Theodros,Czarniecki, Michael,Ahn, Ho-Sam,Boykow, George,Foster, Carolyn,Agans-Fantuzzi, Jacqueline,Bryant, Matthew,Lau, Janice,Chintala, Madhu
, p. 5884 - 5887 (2005)
Structurally novel thrombin receptor (protease activated receptor 1, PAR-1) antagonists based on the natural product himbacine are described. The prototypical PAR-1 antagonist 55 showed a Ki of 2.7 nM in the binding assay, making it the most po
THROMBIN RECEPTOR ANTAGONISTS
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Page 19, (2010/11/30)
Heterocyclic-substituted tricyclics of formula (I) or a pharmaceutically acceptable salt thereof, wherein: the single dotted line represents an optional double bond; the double dotted line represents an optional single bond; n is 0-2; Q is optionally subs