226920-44-1

Upstream product

• 16717-64-9 1-azidostyrene 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 71-43-2 benzene 
• 5428-09-1 3-phthalimido-1-propene 
• 226920-42-9 O-ethyl S-4-oxo-4-phenyl-1-phthalimidomethylbutyl dithiocarbonate 
• 136918-14-4 phthalimide 
• 942-93-8 5-Chloro-1-phenyl-1-pentanone 
• 1575-61-7 5-Chlorovaleroyl chloride 

Downstream Products

• 57050-07-4 2-phenyl-3,4,5,6-tetrahydropyridine 
• 82902-45-2 1-benzoyl-2-phenylpiperidine 
• 3466-80-6 2-phenylpiperidine 

Relevant academic research and scientific papers

Vinyl Azides as Radical Acceptors in the Vitamin B12-Catalyzed Synthesis of Unsymmetrical Ketones

Vinyl azides are very reactive species and as such are useful building blocks, in particular, in the synthesis of N-heterocycles. They can also serve as precursors of ketones. These form in reactions of vinyl azides with nucleophiles or radicals. We have found, however, that under light irradiation vitamin B12 catalyzes the reaction of vinyl azides with electrophiles to afford unsymmetrical carbonyl compounds in decent yields. Mechanistic studies revealed that alkyl radicals are key intermediates in this transformation.

PHENOXYALKYLAMINE COMPOUND

The invention provides a compound having a selective inhibitory activity against highly-expressed LAT-1 in tumor cell. The compound is represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, and a LAT-1 inhibitor comprising the same.

A flexible, convergent approach to piperidines, pyridines, azepines, and related derivatives

A highly convergent approach has been developed for the construction of various nitrogen heterocycles using as the key step the intermolecular addition of an α-ketonyl radical onto a suitably protected allylic or homoallylic amine.