942-93-8

Basic information

• Product Name: 5-chloro-1-phenylpentan-1-one
• Synonyms: 5-chloro-1-phenylpentan-1-one;1-Phenyl-5-chloro-1-pentanone;δ-Chlorovalerophenone;4-Chlorobutyl phenyl ketone;5-Chlorovalerophenone;delta-Chlorovalerophenone
• CAS NO: 942-93-8
• Molecular Formula: C₁₁H₁₃ClO
• Molecular Weight: 196.67332
• EINECS: 213-395-1
• Mol File: 942-93-8.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 304.5°Cat760mmHg
• Flash Point: 162.3°C
• Appearance: /
• Density: 1.081g/cm³
• Vapor Pressure: 0.000871mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 5-chloro-1-phenylpentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-1-phenylpentan-1-one(942-93-8)
• EPA Substance Registry System: 5-chloro-1-phenylpentan-1-one(942-93-8)

Safety Data

• Hazardous Substances Data: 942-93-8(Hazardous Substances Data)

Usage

General Description

5-chloro-1-phenylpentan-1-one, also known as 5-Cl-PP, is an organic compound with the chemical formula C11H13ClO. It is a clear, colorless liquid with a slightly sweet odor that is used as a precursor in the synthesis of pharmaceuticals and other organic compounds. 5-Cl-PP is also known to have various industrial uses, such as in the production of fragrances and flavorings. Its chemical structure contains a chlorine atom and a phenyl group, making it a versatile building block for the creation of a wide range of chemical compounds. Due to its potential for use in the production of various products, 5-chloro-1-phenylpentan-1-one is an important compound in the field of organic chemistry and chemical synthesis.

InChI:InChI=1/C11H13ClO/c12-9-5-4-8-11(13)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2

Upstream product

• 1575-61-7 5-Chlorovaleroyl chloride 
• 1078-58-6 diphenylzinc 
• 700-88-9 cyclopentylbenzene 
• 10487-96-4 1-phenylcyclopentanol 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 20614-62-4 (1-hydroperoxycyclopentyl)benzene 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 120-92-3 cyclopentanone 
• 108-86-1 bromobenzene 
• 6280-87-1 δ-chlorovaleronitrile 
• 100-58-3 phenylmagnesium bromide 
• 138344-21-5 4-Chloro-N,O-dimethylbutyric acid amide 
• 6940-78-9 4-chlorobutyl bromide 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 34008-70-3 5-methoxy-1-phenyl-pentan-1-one 
• 28353-03-9 6-oxo-6-phenylhexanenitrile 
• 66860-66-0 δ-(Butylthio)valerophenone 
• 66860-65-9 δ-(Thiocyanato)valerophenone 
• 66860-69-3 1-phenyl-5-(phenylthio)pentan-1-one 
• 104311-89-9 4,5-epoxy-5-phenyl-1-chloropentane 
• 66860-64-8 5-iodo-1-phenyl-1-pentanone 
• 69573-42-8 5-azido-1-phenylpentan-1-one 
• 3240-29-7 1-Phenylpent-4-en-1-one 
• 98-86-2 acetophenone 
• 31848-96-1 7-chloro-3-phenylheptan-3-ol 
• 226920-44-1 2-(5-oxo-5-phenylpentyl)isoindole-1,3-dione 
• 123463-27-4 (S)-5-chloro-1-phenylpentan-1-ol 
• 37472-54-1 UN⁽¹⁰⁰⁾C₁₀₀₀₇A 

Relevant articles and documents

In-situ-generation of alkylsilyl peroxides from alkyl hydroperoxides and their subsequent copper-catalyzed functionalization with organosilicon compounds

Alkylsilyl peroxides were generated in situ from the corresponding alkyl hydroperoxides using organosilicon compounds of the type Me3SiX (X = CN, N3, and halogens) and an amine base. Subsequent in situ copper-catalyzed homolytic cleavage of the alkylsilyl peroxides afforded alkyl radicals, which were then trapped with X (X = CN, N3, and halogens) to furnish products with new carbon-carbon, carbon-nitrogen, or carbon-halogen bonds in good to high yields.

Ni-Catalyzed C(sp2)-H alkylation ofN-quinolylbenzamides using alkylsilyl peroxides as structurally diverse alkyl sources

A Ni-catalyzed direct C-H alkylation ofN-quinolylbenzamides using alkylsilyl peroxides as alkyl-radical precursors is described. The reaction forms a new C(sp3)-C(sp2) bondviathe selective cleavage of both C(sp3)-C(sp3) and C(sp2)-H bonds. This transformation shows a high functional-group tolerance and, due to the structural diversity of alkylsilyl peroxides, a wide range of alkyl chains including functional groups and complex structures can be introduced at theortho-position of readily availableN-quinolylbenzamide derivatives. Mechanistic studies suggest that the reaction involves a radical mechanism.

Cu-Catalyzed: O -alkylation of phenol derivatives with alkylsilyl peroxides

A Cu-catalyzed O-alkylation of phenol derivatives using alkylsilyl peroxides as alkyl radical precursors is described. The reaction proceeds smoothly under mild reaction conditions and the use of two different ligands with a Cu catalyst provides a wide range of products. A mechanistic study suggested that the reaction proceeds via a radical mechanism. This journal is