226930-26-3Relevant articles and documents
Practical one-pot syntheses of ethyl 4-substituted-1 H-pyrrole-3- carboxylates from aldehydes
Chang, Jay Hyok,Shin, Hyunik
, p. 291 - 293 (2013/01/03)
Ethyl 4-substituted-1H-pyrrole-3-carboxylates were prepared in a one-pot manner starting from aromatic or aliphatic aldehydes via a Horner-Wadsworth- Emmons reaction and subsequent reaction with tosylmethylisocyanide (TosMIC) in the presence of sodium tert-amylate in toluene. Judicious selection of base and solvent led to the use of a single solvent, i.e., toluene, for reactions as well as for crystallization to render the one-pot process more practical and greener than the stepwise version. hisin@ lels.com.
A novel class of highly potent, selective, and non-peptidic inhibitor of ras farnesyltransferase (FTase)
Lee, Hyunil,Lee, Jinho,Lee, Sangkyun,Shin, Youseung,Jung, Wonhee,Kim, Jong-Hyun,Park, Kiwon,Kim, Kwihwa,Cho, Heung Soo,Ro, Seonggu,Lee, Sunhwa,Jeong, ShinWu,Choi, Taesaeng,Chung, Hyun-Ho,Koh, Jong Sung
, p. 3069 - 3072 (2007/10/03)
Design, synthesis and structure-activity relationship of a class of aryl pyrroles as farnesyltransferase inhibitors are described. In vitro and in vivo evaluation of a panel of these inhibitors led to identification of 2 (LB42908) as a highly potent (IC50=0.9 nM against H-Ras and 2.4 nM against K-Ras) antitumor agent that is currently undergoing preclinical studies.
