226931-47-1

Basic information

• Product Name: 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER
• Synonyms: 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER;methyl 3-(naphthalen-1-yl)-3-oxopropanoate
• CAS NO: 226931-47-1
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24
• Mol File: 226931-47-1.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER(226931-47-1)
• EPA Substance Registry System: 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER(226931-47-1)

Safety Data

• Hazardous Substances Data: 226931-47-1(Hazardous Substances Data)

Usage

General Description

3-Naphthalen-1-yl-3-oxo-propionic acid methyl ester is a chemical compound with the molecular formula C14H12O3. It is a methyl ester of 3-naphthalen-1-yl-3-oxo-propionic acid, and is mainly used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical compounds. It is also used in organic synthesis as a reagent for the preparation of other chemical compounds. 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER is a yellowish solid at room temperature and has a molecular weight of 228.24 g/mol. It is important to handle this compound with care, as it may be hazardous to health if not used properly and may cause irritation to the respiratory system, skin, and eyes.

Upstream product

• 86-55-5 1-naphthalenecarboxylic acid 
• 105-45-3 acetoacetic acid methyl ester 
• 306990-95-4 (1H-benzo[d][1,2,3]triazol-1-yl)(naphthalen-1-yl)methanone 
• 941-98-0 1'-naphthacetophenone 
• 616-38-6 carbonic acid dimethyl ester 
• 38330-80-2 monomethyl monopotassium malonate 
• 481075-71-2 N-(1-naphthoyl)imidazole 

Downstream Products

• 76103-97-4 3-(naphthalene-1-yl)-3-oxopropanoic acid 
• 25033-19-6 1-cyclopropyl-naphthalene 
• 78120-50-0 5-naphthalen-1-yl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 1271792-76-7 (R,Z)-methyl 3-(naphthalen-1-yl)-3-(1-phenylethylamino)acrylate 

Relevant articles and documents

Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime

A Cu-catalyzed straightforward synthesis of benzoxazoles from free phenols and cyclic oxime esters is reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of Ezutromid and Flunoxaprofe in one or two steps are demonstrated. A catalytic mechanism, which includes Cu-catalyzed amination via inner-sphere electron transfer and consequent annulation, is proposed.

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

Nickel-catalyzed enantioselective hydrogenation of β-(acylamino)acrylates: Synthesis of chiral β-amino acid derivatives

The nickel-catalyzed asymmetric hydrogenation of β-(acylamino)acrylates has been developed, affording chiral β-amino acid derivatives with excellent yields (95-99% yield) and enantioselectivities (97-99% ee). With the Ni-Binapine system, high enantioselectivities (98-99% ee) have also been obtained in the hydrogenation of Z/E isomeric mixtures of β-alkyl and β-aryl β-(acylamino)acrylates. The synthesis of chiral β-amino acid derivatives on a gram scale has also been achieved with 0.2 mol % catalyst loading.