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226931-47-1

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226931-47-1 Usage

Description

3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER is a chemical compound with the molecular formula C14H12O3. It is a methyl ester of 3-naphthalen-1-yl-3-oxo-propionic acid, characterized by its yellowish solid appearance at room temperature and a molecular weight of 228.24 g/mol. 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER is primarily utilized in the pharmaceutical industry and organic synthesis, necessitating careful handling due to its potential health hazards and irritating properties.

Uses

Used in Pharmaceutical Industry:
3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER serves as an essential intermediate in the synthesis of various pharmaceutical compounds, contributing to the development of new medications and therapies.
Used in Organic Synthesis:
In the realm of organic synthesis, 3-NAPHTHALEN-1-YL-3-OXO-PROPIONIC ACID METHYL ESTER acts as a reagent for preparing other chemical compounds, facilitating the creation of a diverse range of products and materials.

Check Digit Verification of cas no

The CAS Registry Mumber 226931-47-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,9,3 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 226931-47:
(8*2)+(7*2)+(6*6)+(5*9)+(4*3)+(3*1)+(2*4)+(1*7)=141
141 % 10 = 1
So 226931-47-1 is a valid CAS Registry Number.

226931-47-1Relevant articles and documents

Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime

Wang, Zheng-Hai,Wang, Dong-Hui

supporting information, p. 782 - 785 (2022/01/20)

A Cu-catalyzed straightforward synthesis of benzoxazoles from free phenols and cyclic oxime esters is reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of Ezutromid and Flunoxaprofe in one or two steps are demonstrated. A catalytic mechanism, which includes Cu-catalyzed amination via inner-sphere electron transfer and consequent annulation, is proposed.

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

Chen, Li-Jun,Li, Wei,Shen, Bao-Chun,Sun, Zhong-Wen,Xie, Hui-Ding,Zhang, Cong-Cong

supporting information, p. 8607 - 8612 (2021/10/20)

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

Nickel-catalyzed enantioselective hydrogenation of β-(acylamino)acrylates: Synthesis of chiral β-amino acid derivatives

Li, Xiuxiu,You, Cai,Li, Shuailong,Lv, Hui,Zhang, Xumu

supporting information, p. 5130 - 5133 (2017/11/06)

The nickel-catalyzed asymmetric hydrogenation of β-(acylamino)acrylates has been developed, affording chiral β-amino acid derivatives with excellent yields (95-99% yield) and enantioselectivities (97-99% ee). With the Ni-Binapine system, high enantioselectivities (98-99% ee) have also been obtained in the hydrogenation of Z/E isomeric mixtures of β-alkyl and β-aryl β-(acylamino)acrylates. The synthesis of chiral β-amino acid derivatives on a gram scale has also been achieved with 0.2 mol % catalyst loading.

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