227007-93-4Relevant academic research and scientific papers
COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY
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Page/Page column 20, (2009/03/07)
Compounds of general formula (I), wherein X1, X2, X3, R1, R2, R3, Y and Z are as defined herein are useful for the treatment and prevention of Duchenne muscular dystrophy, Becker muscular dystrophy and cachexia.
Ring-ring interconversions. Part 2. Effect of the substituent on the rearrangement of 6-aryl-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazoles into 8-aryl-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones. A novel class of potential antitumor agents
Billi, Roberta,Cosimelli, Barbara,Spinelli, Domenico,Rambaldi, Mirella
, p. 5433 - 5440 (2007/10/03)
The reaction of several 6-aryl-3-methyl-5-nitrosoimidazo[2,1- b][1,3]thiazoles with hydrochloric acid by refluxing in ethanol gives new 8- aryl-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c] [1,2,4]oxadiazol-3-ones for testing of their biological activity. By carrying out the reaction at room temperature it has been possible to isolate reaction intermediates to which structures have been assigned. This study has provided information on the reaction mechanism and on the effect of the substituent in the phenyl ring on the yield of the reaction.
