227023-67-8

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 227023-66-7 (4-Benzyloxy-5-methoxy-2-nitro-phenyl)-(4-cyano-phenylamino)-acetic acid methyl ester 

Downstream Products

• 277325-19-6 methyl (RS)-(4-benzyloxy-5-methoxy-2-phenylacetylamino-phenyl)-(4-cyano-phenylamino)-acetate 
• 227023-66-7 (4-Benzyloxy-5-methoxy-2-nitro-phenyl)-(4-cyano-phenylamino)-acetic acid methyl ester 
• 227023-76-9 {2-(4-benzyloxy-5-methoxy-2-phenylacetylamino-phenyl)-2-[4-(N-hydroxycarbamimidoyl)-phenylamino]-acetylamino}-phenyl-acetic acid 
• 227023-69-0 {2-(2-benzenesulfonylamino-4-benzyloxy-5-methoxy-phenyl)-2-[4-(N-hydroxycarbamimidoyl)-phenylamino]-acetylamino}-phenyl-acetic acid 
• 227023-74-7 (S)-[2-(4-Benzyloxy-5-methoxy-2-phenylacetylamino-phenyl)-2-(4-cyano-phenylamino)-acetylamino]-phenyl-acetic acid methyl ester 
• 227023-75-8 (S)-[2-(4-Benzyloxy-5-methoxy-2-phenylacetylamino-phenyl)-2-(4-cyano-phenylamino)-acetylamino]-phenyl-acetic acid 
• 847896-90-6 (S)-[2-(2-Benzenesulfonylamino-4-benzyloxy-5-methoxy-phenyl)-2-(4-cyano-phenylamino)-acetylamino]-phenyl-acetic acid methyl ester 

Relevant academic research and scientific papers

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors

Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue fac

N-(4-carb-amimidophenyl)glycineamide derivatives

N-(4-carbamimidophenylamino) phenylglycineamide derivative compounds having the formula: in which E, g1, g2, Q, R and X1 to X4 are each as defined in the description, and hydrates or solvates and physiologically acceptable salts thereof can be used as inhibitors of the formation of the coagulation factors Xa, IXa and thrombin induced by the factor VIIa and by the tissue factor. These compounds can be used as medicaments for the treatment and/or prevention of thromboses, apoplexy, cardiac infarction, inflammation and arteriosclerosis or as antitumor agents.