227089-27-2Relevant academic research and scientific papers
IMAGING THE CENTRAL NERVOUS SYSTEM
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, (2011/02/25)
The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X7 receptors in a subject, as a means to facilitate the diagnosis of a range of disease states.
Novel P2X7 receptor antagonists.
Alcaraz,Baxter,Bent,Bowers,Braddock,Cladingboel,Donald,Fagura,Furber,Laurent,Lawson,Mortimore,McCormick,Roberts,Robertson
, p. 4043 - 4046 (2007/10/03)
The synthesis and pharmacological evaluation of a new series of potent P2X(7) receptor antagonists is disclosed. The compounds inhibit BzATP-mediated pore formation in THP-1 cells. The distribution of the P2X(7) receptor in inflammatory cells, most notabl
