2212-06-8

Basic information

• Product Name: 2-[(4-BROMOPHENOXY)METHYL]OXIRANE
• Synonyms: 2-[(4-BROMOPHENOXY)METHYL]OXIRANE;BROMOPHENYL GLYCIDYL ETHER;((4-bromophenoxy)methyl)-oxiran;((4-bromophenoxy)methyl)oxirane;1-(p-bromophenoxy)-2,3-epoxy-propan;1-(p-Bromophenoxy)-2,3-epoxypropane;4-Bromophenyl glycidyl ether;4-bromophenylglycidylether
• CAS NO: 2212-06-8
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• EINECS: 218-656-3
• Mol File: 2212-06-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 51-52 °C
• Boiling Point: 296°Cat760mmHg
• Flash Point: 138.1°C
• Appearance: /
• Density: 1.527g/cm³
• Vapor Pressure: 0.00259mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 2-[(4-BROMOPHENOXY)METHYL]OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-BROMOPHENOXY)METHYL]OXIRANE(2212-06-8)
• EPA Substance Registry System: 2-[(4-BROMOPHENOXY)METHYL]OXIRANE(2212-06-8)

Safety Data

• Hazardous Substances Data: 2212-06-8(Hazardous Substances Data)

Usage

General Description

"2-[(4-Bromophenoxy)methyl]oxirane" is a chemical compound that is categorized in the group of Organobromides and Epoxides. It includes elements such as Bromine, Carbon, Hydrogen, and Oxygen. Due to the presence of the epoxide group, it has a three-membered cyclic ether ring, which makes it highly reactive. It is generally used in research and in various chemical applications due to its ability to react with a broad range of substances. The typical appearance of this chemical is colorless liquid, and it may require special care and safe handling procedures due to its high reactivity and potential health risks.

InChI:InChI=1/C9H9BrO2/c10-7-1-3-8(4-2-7)11-5-9-6-12-9/h1-4,9H,5-6H2

Upstream product

• 106-41-2 4-bromo-phenol 
• 106-89-8 epichlorohydrin 
• 25244-30-8 4-(allyloxy)bromobenzene 
• 70303-33-2 C₉H₉BrO₄S 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 108-95-2 phenol 
• 122-60-1 Phenyl glycidyl ether 
• 96-23-1 1,3-Dichloro-2-propanol 

Downstream Products

• 70193-54-3 4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-benzoic acid propyl ester 
• 70193-58-7 4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-benzoic acid allyl ester 
• 70193-63-4 3-{4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-phenyl}-propionic acid allyl ester 
• 70193-59-8 4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-benzoic acid 2-methoxy-ethyl ester 
• 70193-53-2 4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-benzoic acid methyl ester 
• 70193-61-2 (E)-3-{4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-phenyl}-acrylic acid prop-2-ynyl ester 
• 70193-62-3 (E)-3-{4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-phenyl}-acrylic acid 2-methoxy-ethyl ester 
• 70193-64-5 3-{4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-phenyl}-propionic acid prop-2-ynyl ester 
• 70193-60-1 (E)-3-{4-[3-(4-Bromo-phenoxy)-2-oxo-propoxy]-phenyl}-acrylic acid isopropyl ester 
• 106-41-2 4-bromo-phenol 
• 32017-84-8 1-methoxy-3-phenoxy-propan-2-ol 
• 122-60-1 Phenyl glycidyl ether 
• 95681-94-0 1-(4-bromophenoxy)-3-methoxypropan-2-ol 
• 108-95-2 phenol 

Relevant articles and documents

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Switchable Chemoselectivity of Reactive Intermediates Formation and Their Direct Use in A Flow Microreactor

A chemoselectivity switchable microflow reaction was developed to generate reactive and unstable intermediates. The switchable chemoselectivity of this reaction enables a selection for one of two different intermediates, an aryllithium or a benzyl lithium, at will from the same starting material. Starting from bromo-substituted styrenes, the aryllithium intermediates were converted to the substituted styrenes, whereas the benzyl lithium intermediates were engaged in an anionic polymerization. These chemoselectivity-switchable reactions can be integrated to produce polymers that cannot be formed during typical polymerization reactions.

Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray analysis. A preliminary computational study disclosed that the πsystem of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity.