227095-57-0Relevant academic research and scientific papers
Lipase-mediated kinetic resolution of cis-1,2-indandiol and the Ritter reaction of its mono-acetate
Nakano, Shigeru,Igarashi, Yoshio,Nohira, Hiroyuki
, p. 59 - 62 (2001)
Lipase-mediated kinetic resolution of cis-1,2-indandiol 5 in the presence of lipase PS was examined. Enantiomerically enriched (1S,2R)-2-acetoxy-1-indanol 6a was obtained when cis-1,2-indandiol 5 was treated with one equivalent of vinyl acetate. Treatment of 5 with two equivalents of vinyl acetate furnished a mixture of (1R,2S)-2-acetoxy-1-indanol 6a and (1R,2S)-1-acetoxy-2-indanol 6b. A route to both enantiomers of 1 was also developed by using the enantiomerically enriched mono-acetate thus obtained.
