227098-01-3Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase
Charvat, Trevor T.,Lee, Deborah J.,Robinson, W. Edward,Chamberlin, A. Richard
, p. 4552 - 4567 (2007/10/03)
A series of analogs of the potent HIV-1 integrase (HIV IN) inhibitor chicoric acid (CA) was designed with the intention of ameliorating some of the parent natural product's undesirable properties, in particular its toxicity, instability, and poor membrane
Chicoric acid analogues as HIV-1 integrase inhibitors
Lin, Zhaiwei,Neamati, Nouri,Zhao, He,Kiryu, Yoshimitsu,Turpin, Jim A.,Aberham, Claudia,Strebel, Klaus,Kohn, Kurt,Witvrouw, Myriam,Pannecouque, Christophe,Debyser, Zeger,De Clercq, Erik,Rice, William G.,Pommier, Yves,Burke Jr., Terrence R.
, p. 1401 - 1414 (2007/10/03)
The present study was undertaken to examine structural features of L- chicoric acid (3) which are important for potency against purified HIV-1 integrase and for reported cytoprotective effects in cell-based systems. Through a progressive series of analogu
