2271-34-3

Usage

Uses

Used in Pharmaceutical Industry:
(11E)-hexadec-11-enoic acid is used as an antidiabetic agent for its potential to modulate glucose metabolism and improve insulin sensitivity. This fatty acid has been identified for its ability to reduce blood glucose levels and improve glycemic control in diabetic patients.
Used in Food Industry:
(11E)-hexadec-11-enoic acid is used as a natural component in various food products, particularly in olive oil, due to its presence in olives. It contributes to the unique taste, aroma, and health benefits associated with olive oil consumption.
Used in Cosmetic Industry:
(11E)-hexadec-11-enoic acid can be used as an ingredient in cosmetic products, such as creams and lotions, due to its potential moisturizing and skin conditioning properties. Its presence in olive oil-based cosmetic formulations may provide additional health benefits to the skin.

Upstream product

• 110-62-3 pentanal 
• 189025-37-4 11-(Triphenyl-λ⁵-phosphanylidene)-undecanoic acid ethyl ester 
• 2104-19-0 azelaic monomethyl ester 
• 49580-58-7 (Z)-non-4-enoic acid 
• 55000-41-4 Hexadec-11-ynoic acid methyl ester 
• 85318-87-2 10-ethoxycarbonyldecanal 
• 130074-73-6 ethyl (11Z)-hexadec-11-enoate 
• 50530-12-6 10-bromodecanoic acid 
• 55099-31-5 ethyl 10-bromo-decanoate 
• 693-02-7 hex-1-yne 
• 55182-79-1 5-Decinsaeure 
• 15295-70-2 dec-5-ynenitrile 
• 3416-74-8 1-chloro-4-nonyne 
• 76470-04-7 11-hexadecynoic acid 

Relevant academic research and scientific papers

NOVEL GLYCINE TRANSPORT INHIBITORS FOR THE TREATMENT OF PAIN

The present invention relates to novel glycine transport inhibitor compounds and their use for treating pain.

Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2

It has been demonstrated previously that the endogenous compound N-arachidonyl-glycine inhibits the glycine transporter GlyT2, stimulates glycinergic neurotransmission, and provides analgesia in animal models of neuropathic and inflammatory pain. However, it is a relatively weak inhibitor with an IC50 of 9 μM and is subject to oxidation via cyclooxygenase, limiting its therapeutic value. In this paper we describe the synthesis and testing of a novel series of monounsaturated C18 and C16 acyl-glycine molecules as inhibitors of the glycine transporter GlyT2. We demonstrate that they are up to 28 fold more potent that N-arachidonyl-glycine with no activity at the closely related GlyT1 transporter at concentrations up to 30 μM. This novel class of compounds show considerable promise as a first generation of GlyT2 transport inhibitors.

Preparation of 9-alkenyl ester compounds

Process for the production of 9-alkenyl acetates is provided. The process comprises first disproportionating cyclooctene with an α-olefin to give a 1,9-alkadiene. The alkadiene is metallated to form a 1-metallo-9-alkene, which is then contacted with oxygen to produce a 9-alkenyl-1-oxymetallo compound, which is optionally hydrolyzed to the corresponding alcohol, with the alcohol being esterified to the desired 9-alkenyl ester or the 9-alkenyl-1-oxymetallo compound can be directly esterified, to produce the desired 9-alkenyl esters.

Kolbe Synthesis of Unsaturated Pheromones by Coelectrolysis with 5-Alkynoic Acids

The alkynoic acids 5a - g are synthesized by coelectrolysis of 5-alkynoic acids 2a - c with dicarboxylic monoesters 3a - d.By reduction, Lindlar-hydrogenation, and acetylation these are converted into pheromones such as (Z)-11-hexadecenyl acetate (7b), the pheromone of Mamestra brassicae. 2a - c can be prepared by alkynylation of 1-bromo-3-chloropropane to 1a - c, substitution by cyanide and hydrolysis.