22715-27-1

Basic information

• Product Name: 2,5-Diaminopyrimidine
• Synonyms: 2,5-DIAMINOPYRIMIDINE;2,5-Pyrimidinediamine (9CI);pyrimidine-2,5-diamine;2,5-Pyrimidinediamine;2,5-Diaminepyrimidine;(2-aminopyrimidin-5-yl)amine;Pyrimidine, 2,5-diamino-
• CAS NO: 22715-27-1
• Molecular Formula: C₄H₆N₄
• Molecular Weight: 110.12
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 22715-27-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 200 °C
• Boiling Point: 401.7 °C at 760 mmHg
• Flash Point: 225.6 °C
• Appearance: /
• Density: 1.368 g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.83±0.10(Predicted)
• CAS DataBase Reference: 2,5-Diaminopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Diaminopyrimidine(22715-27-1)
• EPA Substance Registry System: 2,5-Diaminopyrimidine(22715-27-1)

Safety Data

• Hazardous Substances Data: 22715-27-1(Hazardous Substances Data)

Usage

General Description

2,5-Diaminopyrimidine is a chemical compound with the molecular formula C4H6N4. It is a heterocyclic organic compound that consists of a pyrimidine ring with two amino groups attached at the 2 and 5 positions. This chemical is commonly used in the production of pharmaceuticals, especially as a precursor in the synthesis of various drugs. It also has applications in the field of hair care, where it is included as an active ingredient in some hair growth treatments. Additionally, 2,5-Diaminopyrimidine has been studied for its potential antibacterial and antifungal properties, making it a versatile compound with various industrial and medicinal uses.

InChI:InChI=1/C4H6N4/c5-3-1-7-4(6)8-2-3/h1-2H,5H2,(H2,6,7,8)

Upstream product

• 59690-85-6 N-(5-aminopyrimidin-2-yl)acetamide 
• 3073-77-6 5-nitropyrimidin-2-amine 

Downstream Products

• 1001341-11-2 N-(2-amino-pyrimidin-5-yl)-2-chloro-5-(3-trifluoromethyl-benzoylamino)benzamide 
• 925896-84-0 N-(2-aminopyrimidin-5-yl)-2-methyl-5-nitrobenzamide 
• 554-68-7 triethylamine hydrochloride 
• 139522-11-5 N,N'-(pyrimidine-2'',5''-diyl)bis 

Relevant articles and documents

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity

Bruton's tyrosine kinase (Btk) is an attractive drug target for treating several B-cell lineage cancers. Ibrutinib is a first-in-class covalent irreversible Btk inhibitor and has demonstrated impressive effects in multiple clinical trials. Herein, we present a series of novel 2,5-diaminopyrimidine covalent irreversible inhibitors of Btk. Compared with ibrutinib, these inhibitors exhibited a different selectivity profile for the analyzed kinases as well as a dual-action mode of inhibition of both Btk activation and catalytic activity, which counteracts a negative regulation loop for Btk. Two compounds from this series, 31 and 38, showed potent antiproliferative activities toward multiple B-cell lymphoma cell lines, including germinal center B-cell-like diffuse large B cell lymphoma (GCB-DLBCL) cells. In addition, compound 31 significantly prevented tumor growth in a mouse xenograft model.

Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: Synthesis, structure-activity relationships, and inhibition of in vivo T cell activation

The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells. Genetic evidence, including knockout mice and human mutations, demonstrates that Lck kinase activity i