22717-42-6

Basic information

• Product Name: 3H-Pyrazole-3-thione, 2,4-dihydro-5-methyl-2-phenyl-
• Synonyms: 3-methyl-1-phenyl-2-pyrazoline-5-thione;3-methyl-1-phenyl-4,5-dihydropyrazole-5-thione;1-phenyl-3-methylpyrazol-2-in-5-thione;3-methyl-1-phenylpyrazole-5-thione;1-phenyl-3-methyl-2-pyrazolin-5-thione;3-methyl-1-phenyl-2-pyrazolin-5-thione;3H-Pyrazole-3-thione,2,4-dihydro-5-methyl-2-phenyl;1-phenyl-3-methyl-2-pyrazoline-5-thione
• CAS NO: 22717-42-6
• Molecular Formula: C10H10N2S
• Molecular Weight: 190.269
• Mol File: 22717-42-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazole-3-thione, 2,4-dihydro-5-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazole-3-thione, 2,4-dihydro-5-methyl-2-phenyl-(22717-42-6)
• EPA Substance Registry System: 3H-Pyrazole-3-thione, 2,4-dihydro-5-methyl-2-phenyl-(22717-42-6)

Safety Data

• Hazardous Substances Data: 22717-42-6(Hazardous Substances Data)

Upstream product

• 89-25-8 edaravone 

Downstream Products

• 68528-91-6 4-furfurylidene-5-methyl-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 96128-68-6 5-Methyl-4-[(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-(3-nitro-phenyl)-methyl]-2,4-dihydro-pyrazol-3-one 
• 89334-96-3 1-phenyl-3-methyl-4-yl-(1'-phenyl-3'-methyl-2'-pyrazolin-5'thione)-2-pyrazolin-5-one 
• 24637-92-1 4-(anilinomethylene)-3-methyl-1-phenyl-2-pyrazoline-5-thione 
• 89335-00-2 1-phenyl-3-methyl-4-yl-(1'-phenyl-3'-methyl-2'-pyramzolin-5'-thione)-2-pyrazolin-5-thione 
• 96128-57-3 4-[(2-Hydroxy-phenyl)-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 96128-64-2 4-[(2-Hydroxy-phenyl)-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-5-methyl-2,4-dihydro-pyrazol-3-one 
• 96128-69-7 5-Methyl-4-[(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-(4-nitro-phenyl)-methyl]-2,4-dihydro-pyrazol-3-one 
• 96128-58-4 4-[(3-Hydroxy-phenyl)-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 96128-66-4 4-[(4-Hydroxy-phenyl)-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-5-methyl-2,4-dihydro-pyrazol-3-one 
• 121998-91-2 4-bromo-3-methyl-1-phenyl-2-pyrazoline-5-thione 
• 1026032-53-0 2,3-diaza-4-methyl-2-phenyl-9-cyano-8-amino-1-thio-spiro[5.4]-dec-3,8-diene 

Relevant articles and documents

One-Pot Two-Step Synthesis of Isochromene-Fused CF3-Substituted Pyrazoles

An efficient one-pot, two step method for fusing two biologically active motifs, CF3-substituted pyrazoles and isochromenes, was developed. Selective O-benzylation of CF3-substituted pyrazolones and subsequent Pd-catalyzed direct C–H arylation generate a fused tricycle. For the synthesized compounds through-space 13C–19F spin–spin coupling was revealed. In addition, the synthesis of three thioisochromene analogues, and one isocoumarin derivative, was accomplished.

An efficient synthesis of some thiopyranopyrazole-heterocycles via domino reaction in a Bronsted acidic ionic liquid

The thiopyrazole gave many new polycyclic thiopyranopyrazole-heterocycles when it was assembled with a variety of O-alkenylated/alkynylated salicylaldehydes and naphthaldehydes in Bronsted acidic ionic liquid, [Hmim]HSO4, via domino/Knoevenagel-hetero-Diels-Alder (DKHDA) reaction. The reaction is highly stereoselective and the work-up procedure required no chromatography of products in many cases.