227183-66-6Relevant articles and documents
Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p-carborane cages
Kaise, Asako,Ohta, Kiminori,Fujii, Shinya,Oda, Akifumi,Goto, Tokuhito,Endo, Yasuyuki
, p. 3805 - 3811 (2018)
Based on the co-crystal structure of bicalutamide with a T877A-mutated androgen receptor (AR), glycerol and aminoglycerol derivatives were designed and synthesized as a novel type of carborane-containing AR modulators. The (R)-isomer of 6c, whose chiralit