22719-82-0

Upstream product

• 64-17-5 ethanol 
• 29430-39-5 m-tolyl chloroformate 
• 541-41-3 chloroformic acid ethyl ester 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 54373-48-7 carbonic acid ethyl ester-(4-chloromethyl-3-methyl-phenyl ester) 
• 108-39-4 3-methyl-phenol 
• 883568-16-9 2(R/S)-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-2-methylphenyl)propionic acid 
• 305859-79-4 2-acetylamino-2-(4-hydroxy-2-methyl-benzyl)-malonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis, antifungal activity, and molecular docking studies of novel triazole derivatives

In order to meet the urgent need for novel antifungal agents with improved activity and broader spectrum, a series of 3/4-[[N-alkyl-2-(2,4-difluorophenyl)- 2-hydroxy-3-(1H-1, 2, 4-triazole)] propylamino] benzylethyl carbonate were designed, synthesized and evaluated as antifungal agents. The MIC80 values indicate that all the compounds showed only moderate or even no antifungal activities against nearly all the tested fungal pathogens. Moreover, the interactions of the most active compounds in the drug binding site of CACYP51 were also explored with the help of docking studies.

Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors

Fifteen analogues of the C-terminal CA1A2X motif were synthesized and evaluated for their inhibition potency against farnesyltransferase (FTase). Replacement of the A2 residue by phenylalanine or tyrosine-derived analogues, in which a different number of methyl groups were introduced on the aromatic ring, resulted in compounds less active than the reference compound CVFM against FTase except for compounds I and VI (IC50 = 1 μM and 2.5 μM, respectively) that were comparable to CVFM and compound IV (IC50 = 0.1 μM), which was 6-fold more active than the reference compound. Because pseudopeptidic derivatives I-IX were inactive in the cellular assays, the N-formyl- and methyl-ester derivatives (compounds X-XV) were synthesized and tested on different cell lines, showing, in some cases, activity and appreciable selectivity against transformed cells. To rationalize the obtained results, molecular modeling experiments were carried out suggesting the molecular basis of FTase inhibition by these products.

Sodium Hydrogen Telluride- An Efficient Reagent for Deblocking of Aryl Ethyl Carbonates

Sodium hydrogen telluride is found to be a mild and efficient reagent for deblocking of aryl ethyl carbonates.