227196-07-8Relevant academic research and scientific papers
Stereoselective synthesis of myo-, neo-, L-chiro, D-chiro, allo-, scyllo-, and epi-inositol systems via conduritols prepared from p-benzoquinone
Podeschwa, Michael,Plettenburg, Oliver,Vom Brocke, Jochen,Block, Oliver,Adelt, Stephan,Altenbach, Hans-Josef
, p. 1958 - 1972 (2007/10/03)
A practical route is described for the flexible preparation of a wide variety of inositol stereoisomers and their polyphosphates. The potential of this approach is demonstrated by the synthesis of myo-, L-chiro-, D-chiro-, epi-, scyllo-, allo-, and neo-inositol systems. Optically pure compounds in either enantiomeric form can be prepared from p-benzoquinone via enzymatic resolution of a derived conduritol B key intermediate. High-performance anion-exchange chromatography with pulsed amperometric detection permits inositol stereoisomers to be resolved and detected with high sensitivity. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
Synthesis, calcium mobilizing, and physicochemical properties of D- chiro-inositol 1,3,4,6-tetrakisphosphate, a novel and potent ligand at the D- myo-inositol 1,4,5-trisphosphate receptor
Liu, Changsheng,Davis, Richard J.,Nahorski, Stefan R.,Ballereau, Stephanie,Spiess, Bernard,Potter, Barry V.L.
, p. 1991 - 1998 (2007/10/03)
The synthesis of a novel and potent ligand at the D-myo-inositol 1,4,5- trisphosphate receptor (InsP3R) is described. D-chiro-Inositol 1,3,4,6- tetrakisphosphate (7) and L-chiro-inositol 1,3,4,6-tetrakisphosphate (ent-7) have been synthesized f
