22727-84-0

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 618-40-6 1-Methyl-1-phenylhydrazine 

Downstream Products

• 521093-78-7 2-amino-1-(N-methylanilino)-5-oxo-4-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 521093-77-6 2-amino-4-(4-bromophenyl)-1-(N-methylanilino)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of α,β-Dicarbonylhydrazones by Aerobic Manganese-Catalysed Oxidation

A practical, simple, and efficient manganese-catalysed oxidation of C(sp2)?H bond in readily available β-carbonylenehydrazine under aerobic conditions has been developed. This protocol exhibits a wide range of functional group tolerance in β-carbonylenehydrazines to afford α,β-dicarbonylhydrazones. Experimental and theoretical results suggest that the reaction very likely proceeds through a radical pathway via a hydrogen-atom-transfer process promoted by a MnIII species. (Figure presented.).

Synthesis of 12-aryl-1-oxo-1,2,3,4,5,12-hexahydroindolo[2,1-b]quinazoline-6-carbonitriles by recyclization of 11-aryl-1-oxo-2,3,4,5,10b,11-hexahydro-1H-indolo[2,3-b] quinoline-10b-carbonitriles

A general and convenient method for the synthesis of 12-aryl-1-oxo-1,2,3,4,5,12-hexahydroindolo[2,1-b]quinazoline-6-carbonitriles was proposed. The method is based on the recyclization of 11-aryl-1-oxo-2,3,4,5,10b,11-hexahydro-1H-indolo[2,3-b] quinoline-10b-carbonitriles. The structure of 12-(3-methoxyphenyl)-8-methyl-1-oxo-1,2,3,4,5,12-hexahydroindolo[2,1-b] quinazoline-6-carbonitrile was studied by X-ray diffraction analysis.