2273-04-3

Basic information

• Product Name: Urea, (2-nitrophenyl)-
• CAS NO: 2273-04-3
• Molecular Formula: C7H7N3O3
• Molecular Weight: 181.151
• Mol File: 2273-04-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Urea, (2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, (2-nitrophenyl)-(2273-04-3)
• EPA Substance Registry System: Urea, (2-nitrophenyl)-(2273-04-3)

Safety Data

• Hazardous Substances Data: 2273-04-3(Hazardous Substances Data)

Upstream product

• 3320-86-3 2-nitrophenyl isocyanate 
• 60095-87-6 (2-nitrophenyl)azo 4-methylphenyl sulfone 
• 7647-01-0 hydrogenchloride 
• 5465-98-5 2-nitrophenylcyanamide 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 88-74-4 2-nitro-aniline 
• 14527-90-3 2-nitroaniline hydrochloride 
• 13725-30-9 methyl N-(2-nitrophenyl)carbamate 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 2769-72-4 tert-Butyl isocyanoacetate 
• 590-28-3 potassium cyanate 
• 63451-02-5 (2-nitro-phenyl)-carbamoyl chloride 

Downstream Products

• 22751-18-4 N-(2,4-dinitro-phenyl)-N'-nitro-urea 
• 1025364-96-8 2-(3-(2-thien-2-ylethyl)thioureido)-4-morpholin-4-yl-6-(3-(2-nitrophenyl)ureido)-s-triazine 
• 1401252-78-5 3-(2-nitrophenylureido)carbonyl-N₁-ethyl-6-hydroxy-4-oxo-pyrido[2,3-h]quinoline 
• 1333415-70-5 C₁₃H₁₁N₃O₅ 
• 921933-23-5 cyclohexyl-(1-oxy-benzo[1,2,4]triazin-3-yl)-amine 
• 121745-82-2 N-phenyl-1,2,4-benzotriazin-3-amine 1-oxide 
• 54215-05-3 2-[(1-oxido-1,2,4-benzotriazin-3-yl)amino]ethanol 
• 67692-91-5 3-chloro-1,2,4-benzotriazine 1-oxide 

Relevant articles and documents

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.

Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives

A series of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives 1 have been synthesized and evaluated for their cytotoxic activity in vitro against human leukemia cell lines: Molt-4, K562, HL60, human liver cancer cell Hep-G2, human prostate cancer cell PC-3 in hypoxia. Most of the compounds showed more potent activity than TPZ. Compounds 1i and 1m displayed encouraging superior activity against Molt-4 and HL-60 cell lines. Three potential derivatives received the test of the activity in hypoxia and in normoxia against Molt-4 and HL-60 cell lines and showed obvious hypoxia selectivity. Further mechanism study revealed that the cytotoxic activities of compounds 1i and 1k in Molt-4 cells might be mediated by modulation of p53 protein expression and mitochondrial membrane potential (ΔΨm).

N-Nitroaryl-N-halosulfonyl ureas

N-o-nitro-phenyl- or -naphthyl-N'-halogensulfonyl ureas which may be substituted in their aromatic rings by a further nitro group (and the phenyl ureas also by fluoro, chloro, bromo, lower alkyl, lower alkoxy, trifluoromethyl, cyano or phenyl) are obtaine