22730-59-2

Basic information

• Product Name: [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester
• Synonyms: [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester
• CAS NO: 22730-59-2
• Molecular Weight: 373.773
• Mol File: 22730-59-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester(22730-59-2)
• EPA Substance Registry System: [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester(22730-59-2)

Safety Data

• Hazardous Substances Data: 22730-59-2(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 
• 122-52-1 triethyl phosphite 
• 2169-68-8 ethyl (E)-3-(4-chlorophenyl)-2-cyanoacrylate 

Relevant articles and documents

Nanosized zinc oxide as a catalyst for the rapid and green synthesis of β-phosphono malonates

The design and development of a nano heterogeneous catalyst for the direct addition of P(O)-H bonds across various alkylidenes under solvent-free conditions is described. This is a mild, rapid, and efficient protocol to generate P-C bonds.

Synthesis of 2-amino-4H-chromen-4-ylphosphonates and β-phosphonomalonates via tandem Knoevenagel–Phospha-Michael reaction and antimicrobial evaluation of newly synthesized β-phosphonomalonates

In this manuscript we have demonstrated a new approach for the synthesis of 2-amino-4H-chromen-4-ylphosphonates and β-phosphonomalonates linked 2-chloroquinoline-3-carbaldehyde by modified one-pot three-component tandem Knoevenagel–Phospha-Michael reaction of salicylaldehyde/aryl aldehyde/2-chloroquinoline-3-carbaldehyde, malononitrile/ethylcyanoacetate, and phosphite ester using triethylamine (1–10?mol%) in ethanol under reflux conditions. The desired products were obtained in 86–97% yield in 8–35?h. The advantages of this protocol are its operational simplicity, low catalytic loading, no side product formation, and high yield of product. The newly synthesized β-phosphonomalonates, diethyl-(2-chloroquinolin-3-yl)-2,2-dicyanoethyl)-phosphonates (4a–i) have been tested on two fungal strains (C. albicans and A. fumigatus) and two bacterial strains (S. aureus and E. coli) and their minimum inhibitory concentration was also determined by microbroth dilution method.

A quaternary ammonium salt [H-dabco][AcO]: As a recyclable and highly efficient catalyst for the one-pot synthesis of β-phosphonomalonates

A simple, green and highly efficient approach for the one-pot three-component synthesis of β-phosphonomalonates has been developed. In the presence of the quaternary ammonium salt catalysts, the β-phosphonomalonates were obtained in excellent yields within short times via tandem Knoevenagel-phospha-Michael reaction. The reaction of aldehydes/ketones, active methylene compounds, and diethyl phosphite performed at room temperature under solvent-free conditions. No column purification is required and the products can be purified by simple crystallization. The catalysts can be easily recovered and reused several times without significant activity loss. This journal is