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Relevant academic research and scientific papers

Nanosized zinc oxide as a catalyst for the rapid and green synthesis of β-phosphono malonates

The design and development of a nano heterogeneous catalyst for the direct addition of P(O)-H bonds across various alkylidenes under solvent-free conditions is described. This is a mild, rapid, and efficient protocol to generate P-C bonds.

LiBr-catalyzed one-pot three-component domino strategy toward the construction of β-phosphonomalonates scaffolds in aqueous conditions

LiBr-mediated domino Knoevenagel-phospha-Michael strategy has been established for the synthesis of β-phosphonomalonates under aqueous conditions. It is noteworthy that the developed protocol is effective with a wide range of aldehydes to deliver a diverse range of β-phosphonomalonates in good to excellent yields. The mild reaction conditions, easier procedure, use of aqueous media, inexpensive and water tolerant property of LiBr are important advantages of this protocol.

Synthesis of 2-amino-4H-chromen-4-ylphosphonates and β-phosphonomalonates via tandem Knoevenagel–Phospha-Michael reaction and antimicrobial evaluation of newly synthesized β-phosphonomalonates

In this manuscript we have demonstrated a new approach for the synthesis of 2-amino-4H-chromen-4-ylphosphonates and β-phosphonomalonates linked 2-chloroquinoline-3-carbaldehyde by modified one-pot three-component tandem Knoevenagel–Phospha-Michael reaction of salicylaldehyde/aryl aldehyde/2-chloroquinoline-3-carbaldehyde, malononitrile/ethylcyanoacetate, and phosphite ester using triethylamine (1–10?mol%) in ethanol under reflux conditions. The desired products were obtained in 86–97% yield in 8–35?h. The advantages of this protocol are its operational simplicity, low catalytic loading, no side product formation, and high yield of product. The newly synthesized β-phosphonomalonates, diethyl-(2-chloroquinolin-3-yl)-2,2-dicyanoethyl)-phosphonates (4a–i) have been tested on two fungal strains (C. albicans and A. fumigatus) and two bacterial strains (S. aureus and E. coli) and their minimum inhibitory concentration was also determined by microbroth dilution method.

Aqueous microwave-assisted DMAP catalyzed synthesis of β-phosphonomalonates and 2-amino-4H-chromen-4-ylphosphonates via a domino Knoevenagel-phospha-Michael reaction

An aqueous microwave (mw)-assisted DMAP catalyzed one-pot highly efficient route to synthesize β-phosphonomalonates and 2-amino-4H-chromen-4-yl phosphonates has been demonstrated via the domino Knoevenagel-phospha-Michael reaction of aryl aldehyde/salicylaldehyde, malononitrile/ethyl cyanoacetate and alkyl phosphite ester. Optimization of reaction conditions were performed by using conventional and microwave synthetic approaches. This conversion proceeded smoothly to deliver the desired product in good to excellent yields (75–95%) in a short reaction time (10–12?min). The present methodology is very simple, environmentally benign, high yielding and has very well demonstrated the synergistic effect of water and microwaves.

A quaternary ammonium salt [H-dabco][AcO]: As a recyclable and highly efficient catalyst for the one-pot synthesis of β-phosphonomalonates

A simple, green and highly efficient approach for the one-pot three-component synthesis of β-phosphonomalonates has been developed. In the presence of the quaternary ammonium salt catalysts, the β-phosphonomalonates were obtained in excellent yields within short times via tandem Knoevenagel-phospha-Michael reaction. The reaction of aldehydes/ketones, active methylene compounds, and diethyl phosphite performed at room temperature under solvent-free conditions. No column purification is required and the products can be purified by simple crystallization. The catalysts can be easily recovered and reused several times without significant activity loss. This journal is

Pyridine-grafted graphene oxide: a reusable acid-base bifunctional catalyst for the one-pot synthesis of β-phosphonomalonates via a cascade Knoevenagel-phospha Michael addition reaction in water

A new acid-base bifunctional catalyst was synthesized by postgrafting of pyridine onto GO. This new catalyst was characterized by different methods such as FT-IR, XRD, TGA, TEM, SEM, EDS, UV-Vis and elemental analysis and employed as a reusable acid-base bifunctional catalyst for the one-pot synthesis of β-phosphonomalonates via a cascade Knoevenagel-phospha Michael addition reaction of aldehydes, malononitrile and dialkyl phosphites in water.

Lanthanum(III) triflate supported on nanomagnetic γ-Fe 2O3: A new magnetically recyclable heterogeneous Lewis acid for the one-pot synthesis of β-phosphonomalonates

Lanthanum(iii) triflate supported on nanomagnetic γ-Fe 2O3 was synthesized and characterized by HRTEM, XRD, ICP, FT-IR, TGA and VSM. It was applied as a magnetically recyclable heterogeneous Lewis acid catalyst for the efficient one-pot synthesis of β- phosphonomalonates via tandem Knoevenagel-phospha-Michael reaction. The catalyst was easily separated from the reaction mixture by magnetic decantation using an external magnet and reused ten times. This journal is the Partner Organisations 2014.

5-Hydroxypentylammonium acetate as a reusable ionic liquid catalyzes tandem Knoevenagel-phospha-Michael reaction of aldehydes, malononitrile and phosphites

5-Hydroxypentylammonium acetate as a taskspecific ionic liquid promotes efficient tandem Knoevenagel- phospha-Michael reaction of phosphite esters with aryl/heteroaryl/alkyl/salicylaldehydes and malonitrile/ethyl cyanoacetate at room temperature in short

Nano n-propylsulfonated γ-Fe2O3 as magnetically recyclable heterogeneous catalyst for the efficient synthesis of β-phosphonomalonates

Nano n-propylsulfonated γ-Fe2O3 as a new sulfonated nanomagnetic iron oxide was synthesized directly through ring opening reaction of 1,3-propanesultone with nano magnetic γ-Fe2O 3 and used as magnetically recyclable heterogeneous catalyst for the efficient one-pot synthesis of β-phosphonomalonates. The catalyst was easily isolated from the reaction mixture by magnetic decantation using an external magnet and reused at least five times without significant degradation in the activity.

An eco-friendly procedure for one-pot synthesis of β- phosphonomalonates: Micellar solution of sodium stearate catalyzes tandem Knoevenagel-phospha-Michael reaction of aldehydes, malonitrile, and phosphites in aqueous media

A new, one-pot convenient method for the synthesis of a variety of β-phosphonomalonates by a tandem Knoevenagel-phospha-Michael reaction of phosphite esters with aryl/heteroaryl/alkyl aldehydes and malonitrile in an aqueous micellar solution of sodium ste