227450-76-2

Upstream product

• 120-80-9 benzene-1,2-diol 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 248255-75-6 2-methoxy-3-methyl-2-phenyl-2,3-dihydro-benzo[1,4]dioxine 
• 2103-94-8 4-(4-bromophenyl)-1,3-thiazol-2-amine 

Relevant academic research and scientific papers

Clean synthesis of α-bromo ketones and their utilisation in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3-thiazoles using polymer-supported reagents

An array of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxane derivatives and 2-amino-1,3-thiazoles were prepared in high yield using a straightforward three-step and two-step sequence of polymer-supported reagents, respectively and other polymer-supported sequestering reagents without any chromatographic purification step. A key step involves clean and efficient bromination of acetophenones using polymer-supported pyridinium bromide perbromide (PSPBPB) and subsequent cyclisation reaction.

A facile synthesis of 2-hydroxy-2-aryl 1,4-benzodioxanes

Condensation of catechol with 2-bromo-1-aryl-ethanones and 2-bromo-1- aryl-propanones in dry acetone-K2CO3 medium afforded 2-hydroxy-2-aryl-1,4- benzodioxanes in good yield.