227467-45-0Relevant articles and documents
Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same
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Page column 13, (2010/11/29)
The present invention provides novel phenylaminoalkyl-carboxylic acid derivatives represented by the general formula: (wherein R1represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, an alicyclic amino group or a mono or di(lower alkyl)amino group which may have a hydroxy group or a lower alkoxy group as a substituent; R2represents a hydrogen atom or a lower alkyl group; R3represents a hydrogen atom or a halogen atom; R4and R5are the same or different and each represents a hydrogen atom, a halogen atom or a lower alkyl group; A represents a lower alkylene group; the carbon atom marked with (R) represents a carbon atom in (R) configuration; and the carbon atom marked with (S) represents a carbon atom in (S) configuration) and pharmaceutically acceptable salts thereof, which have excellent β3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.
Discovery of novel N-phenylglycine derivatives as potent and selective β3-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence
Tanaka,Tamai,Mukaiyama,Hirabayashi,Muranaka,Akahane,Miyata,Akahane
, p. 1436 - 1445 (2007/10/03)
With a novel assay using isolated ferret detrusor to estimate β3-adrenoceptor agonistic activity, we found that a series of glycine derivatives of ritodrine, a β2-adrenoceptor agonist, are potent β3-adrenoceptor agonists,
