22758-56-1

Basic information

• Product Name: 5-oxo-5-propoxypentanoic acid
• CAS NO: 22758-56-1
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.1944
• Mol File: 22758-56-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 294.3°C at 760 mmHg
• Flash Point: 115°C
• Density: 1.097g/cm³
• Vapor Pressure: 0.000399mmHg at 25°C
• Refractive Index: 1.447
• CAS DataBase Reference: 5-oxo-5-propoxypentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-oxo-5-propoxypentanoic acid(22758-56-1)
• EPA Substance Registry System: 5-oxo-5-propoxypentanoic acid(22758-56-1)

Safety Data

• Hazardous Substances Data: 22758-56-1(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 110-94-1 1,5-pentanedioic acid 
• 1724-48-7 pentanedioic acid dipropyl ester 

Relevant articles and documents

PYRIDIN-2YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF

The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R1=H, R2=H, R3=CH2-COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.

PYRIDIN- 2 - YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF

The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HUVEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS-Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure la, R1 = H, R2 = H, R3 = CH2COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.