2276-90-6

Usage

Uses

Used in Diagnostic Radiology:
Iothalamic acid is used as a contrast medium for various imaging techniques, such as angiography, urography, and computed tomography (CT) scans. It helps in improving the visualization of blood vessels, kidneys, and other internal structures, enabling doctors to detect abnormalities, assess organ function, and diagnose various medical conditions.
Iothalamic acid is used as a contrast medium for [application reason] in diagnostic radiology, where it enhances the visualization of blood vessels, organs, and tissues during imaging procedures.
Chemical Properties:
Iothalamic acid is an off-white solid with water-soluble properties, making it suitable for use as a contrast agent in medical imaging. Its iodine content allows it to absorb X-rays effectively, providing clear and detailed images for accurate diagnosis.
Safety and Nephroprotection:
Iothalamic acid has been found to display the same level of nephrotoxicity against rat and human renal epithelial cells as conventional ionic contrast media. This suggests that it may have similar safety profiles and potential risks associated with its use in diagnostic radiology. However, further research and clinical trials are necessary to fully understand its safety and efficacy in comparison to other contrast agents.

Therapeutic Function

Diagnostic aid (radiopaque medium)

InChI:InChI=1/C11H9I3N2O4/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20/h1-2H3,(H,15,18)(H,16,17)(H,19,20)

Relevant academic research and scientific papers

Iodinated aroyloxy ketones

Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1, R2, R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, acetamidoaryl, --COO-alkyl, --COO-aryl, --COO-aralkyl, --CO-alkyl, --CO-aryl, --CO-heterocyclyl, cyano or heterocyclyl; R5 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, heterocyclyl, or a Z-CO2 -CR1 R2 (CR3 R4)n group, wherein Z, R1, R2, R3, R4 and n are as defined above, m is an integer from 0 to 10, p is an integer from 0 to 10, and m+p≥1 are useful as contrast agents in x-ray imaging compositions and methods.

Iodinated aromatic compounds

Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 6; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; and R5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods.

Polyiodinated aroyloxy esters

Compounds having the structure STR1 wherein Z--COO)m is the residue of a polyiodinated aromatic acid; m is 1, 2, 3 or 4; n is an integer from 1 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; and R5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; are useful as contrast agents in x-ray imaging compositions and methods.

Iodinated benzoyl acetals and ketals for x-ray imaging

Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; R is alkyl, cycloalkyl, aryl, aralkyl, STR2 or alkenyl; R1 is H, alkyl, cycloalkyl, aryl, aralkyl, or --CH2 --m CO2 R3 ; R2 is H, alkyl, cycloalkyl, aryl, aralkyl, --CH2 --n CO2 R4, or a STR3 group, wherein Z, R and R1 are as defined above; or R1 and R2, taken together with the carbon atom to which they are attached represent cycloalkyl; R3 is H, alkyl, cycloalkyl, aryl or aralkyl; R4 is H, alkyl, cycloalkyl, aryl or aralkyl; and m, n and p are independently an integer of from 0 to 17; provided that R1 and R2 can not both be H; are useful in the preparation of x-ray contrast compositions for medical imaging.

Iodinated wetting agents

Compounds having the structure STR1 wherein (Z)--COO is the residue of an iodinated aromatic acid; M is H, a cation, --CH2 CH2 O--m H, and --CH2 CH(OH)O--p H; m is an integer from 1 to 150; p is an integer from 1 to 50; and L is one or more divalent linking groups selected from alkylene, cycloalkylene, arylene, arylenealkylene, and alkylenearylene are particularly useful as wetting agents in x-ray imaging compositions.

Iodinated aroyloxy esters

Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 1 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; and R5 is alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; are useful as contrast agents in x-ray imaging compositions and methods.

Iodinated aromatic propanedioates

Compounds having the structure STR1 where (Z--COO is the residue of an iodinated aromatic acid; R1 and R2 are independently alkyl, fluoroalkyl, cycloalkyl, aryl or aralkyl; and R3 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, cyano, sulfonate, carboxamido, sulfonamido, CO2 -alkyl, CO2 -aryl or CO2 -aralkyl; are useful as contrast agents in x-ray imaging compositions and methods.

Iodinated aroyloxy carboxamides

Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently a substituent as defined for R1 and R2 above, halogen, hydroxy or acylamino; and R5 and R6 are independently H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, alkoxyalkyl, or acetamidoalkyl; or R5 and R6, taken together with the nitrogen atom to which they are attached, represent a 4 to 7-membered nitrogen containing ring, are useful as contrast agents in x-ray imaging compositions and methods.

Non-ionic polyol contrast media from ionic contrast media

Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.