227601-52-7

Upstream product

• 64-19-7 acetic acid 
• 10378-06-0 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)[1,2-d]-2-oxazoline 
• 227601-43-6 allyl-O-<2,4,6-tri-O-benzyl-β-D-galactopyranosyl>-(1->4)-2,3,6-tri-O-benzyl-β-D-glucopyranoside 
• 227601-51-6 allyl-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->3)-O-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->4)-O-2,3,6-tri-O-benzyl-β-D-glucopyranoside 
• 70831-94-6 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-D-glucopyranosyl bromide 
• 3006-60-8 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucopyranose 

Downstream Products

• 227601-53-8 allyl-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1->3)-O-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->4)-O-2,3,6-tri-O-benzyl-β-D-glucopyranoside 
• 227601-54-9 allyl-O-(2-acetamido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranosyl)-(1->3)-O-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->4)-O-2,3,6-tri-O-benzyl-β-D-glucopyranoside 
• 227601-55-0 allyl-O-(2-acetamido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-β-D-glucopyranosyl)-(1->3)-O-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->4)-O-2,3,6-tri-O-benzyl-β-D-glucopyranoside 

Relevant academic research and scientific papers

Synthesis of oligosaccharides related to HNK-1 antigen. 2. synthesis of β-propyl 3?-O-(3-o-sulfo-β-d-glucuronopyranosyl)-lacto-n-tetraoside

A derivative of allyl 3Prime;-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-β-lactoside with a free OH group at C-4GlcNAc was glycosylated with trichloroacetimidate of selectively protected GlcA(β1→3)Galα disaccharide in dichloromethane in the presence of trimethylsilyl inflate, resulting in a pentasaccharide product with an 82% yield. This product was converted to monohydroxy derivative with a free OH group at C-3GlcA via the formation and the subsequent opening of the 6,3-lactone ring in the glucuronic acid residue. The 3-O-sulfation of the monohydroxy derivative, the removal of the protective groups, and the reduction of the allyl aglycon yielded the pentasaccharide propyl glycoside NaSO 3-3GlcA(β1→3)Gal(β1→4)GlcNAc(β1→3) Gal(β1→4)Glcβ-OPr, comprising the oligosaccharide chain of the SGGL-1 glycolipid, which is recognized by HNK-1 antibodies. NaSO3-3GlcA(β1→3)GalβOAll, GlcA(β1→3)Gal(β1→4)GlcNAc(β1→3)Gal(β1→4) GlcβOPr, and GlcA(β1→3)GalβOAll were synthesized in a similar way.