227602-36-0

Upstream product

• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 511268-06-7 (R)-3-[(E)-3-(4-chlorophenyl)prop-2-enoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 227602-28-0 (4R)-N-<5,5-(trimethylenedithio)-2(E),7(E),9-decatrienoyl>-4-phenyloxazolidin-2-one 
• 756900-05-7 (4R)-4-phenyl-3-[(3R,4S,6R)-3,4,6-trimethyl-8-((2S)-N-methyl-2-methylbutyramido)-octanoyl]-2-oxazolidinone 
• 320742-91-4 (4R)-4-phenyl-3-[(3R,4S,6S)-3,4,6-trimethyl-8-((2S)-N-methyl-2-methylbutyramido)-octanoyl]-2-oxazolidinone 
• 756900-02-4 (4R)-phenyl-3-[(4R,6R)-4,6-dimethyl-8-((2S)-N-methyl-2-methylbutyramido)-(E)-2-octenoyl]-2-oxazolidinone 
• 320742-90-3 (4R)-phenyl-3-[(4R,6S)-4,6-dimethyl-8-((2S)-N-methyl-2-methylbutyramido)-(E)-2-octenoyl]-2-oxazolidinone 
• 320742-81-2 (R)-N-((3S,5S,E)-3,5-dimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)oct-6-en-1-yl)-N,2-dimethylbutanamide 
• 320742-82-3 (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide 
• 227602-33-7 diethyl (R)-2-oxo-2-(2-oxo-4-phenyloxazolidin-3-yl)ethylphosphonate 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

HIV PROTEASE INHIBITORS

The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Studies on a total synthesis of plakotenin: Synthesis of optically active trans-hydrindanes by diastereoselective asymmetric intramolecular diels-alder reaction

Diastereoselective asymmetric intramolecular Diels-Alder reaction of 5,5-(trimethylenedithio)-2(E),7(E),9-decatrienoyl amides (13a-e) having various chiral auxiliaries was performed to give optically active trans- hydrindanes, which would be an important