320742-82-3

Basic information

• Product Name: (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide
• Synonyms: (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide
• CAS NO: 320742-82-3
• Molecular Weight: 444.615
• Mol File: 320742-82-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide(320742-82-3)
• EPA Substance Registry System: (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide(320742-82-3)

Safety Data

• Hazardous Substances Data: 320742-82-3(Hazardous Substances Data)

Upstream product

• 123444-68-8 (S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutanal 
• 1351186-11-2 (R)-3-((S,E)-6-(tert-butyldiphenylsilyloxy)-5-methylhex-2-enoyl)-4-phenyloxazolidin-2-one 
• 321162-62-3 Toluene-4-sulfonic acid (1R,2R)-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-methyl-but-3-enyl ester 
• 320742-78-7 (2R)-N-methyl-N-[(3S,5S)-dimethyl-6-(tert-butyldiphenylsilyloxy)-hex-1-yl]-2-methylbutyramide 
• 320742-77-6 (R)-N-((3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-2-methylbutanamide 
• 320742-74-3 Methanesulfonic acid (3S,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexyl ester 
• 227602-33-7 diethyl (R)-2-oxo-2-(2-oxo-4-phenyloxazolidin-3-yl)ethylphosphonate 
• 227602-36-0 (R)-3-(2-bromoacetyl)-4-phenyloxazolidin-2-one 
• 198124-61-7 (3R,4R,5R)-3,5-dimethyl-6-[tert-butyldiphenylsilyloxy]-hex-1-en-4-ol 
• 128329-63-5 (3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexan-1-ol 
• 32231-50-8 (R)-2-methylbutyric acid 
• 75-16-1 methylmagnesium bromide 
• 320742-81-2 (R)-N-((3S,5S,E)-3,5-dimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)oct-6-en-1-yl)-N,2-dimethylbutanamide 
• 1351186-13-4 (R)-3-((3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexanoyl)-4-phenyloxazolidin-2-one 

Downstream Products

• 247184-89-0 (+)-kalkitoxin 
• 1352307-99-3 (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-7-((S)-4-vinyl-4,5-dihydrothiazol-2-yl)heptyl)butanamide 
• 1351186-16-7 (3R,4S,6S)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((S)-1-(tritylthio)but-3-en-2-yl)octanamide 
• 1351186-15-6 (3R,4S,6S)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide 

Relevant articles and documents

Synthesis and biological activity of kalkitoxin and its analogues

Total syntheses of kalkitoxin, isolated from the Caribbean Lyngbya majuscula, and its analogues, 3-epi-, 7-epi-, 8-epi-, 10-epi-, 10-nor-, and 16-nor-kalkitoxin, were achieved via oxazolidinone-based diastereoselective 1,4-addition reaction of a methyl group and efficient TiCl4-mediated thiazoline ring formation as the key steps. The biological activities of synthetic kalkitoxin and its analogues were evaluated with brine shrimp.

Structure, synthesis, and biological properties of kalkitoxin, a novel neurotoxin from the marine cyanobacterium Lyngbya majuscula [24]

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