227609-86-1

Basic information

• Product Name: Benzenemethanol, 3-amino-4-fluoro- (9CI)
• Synonyms: Benzenemethanol, 3-amino-4-fluoro- (9CI);(3-Amino-4-fluorophenyl)methanol, 2-Fluoro-5-(hydroxymethyl)aniline;Benzenemethanol, 3-amino-4-fluoro-
• CAS NO: 227609-86-1
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.1429232
• Product Categories: VARIOUSAMINE
• Mol File: 227609-86-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: 76～78℃
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Benzenemethanol, 3-amino-4-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3-amino-4-fluoro- (9CI)(227609-86-1)
• EPA Substance Registry System: Benzenemethanol, 3-amino-4-fluoro- (9CI)(227609-86-1)

Safety Data

• Hazardous Substances Data: 227609-86-1(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 3-amino-4-fluoro- (9CI) is an organic compound that consists of a benzene ring with an attached amino group and a fluorine atom. It is commonly used as a building block or intermediate in the synthesis of various pharmaceuticals and agrochemicals. This chemical has potential applications in the development of new drugs, as it can be modified to create compounds with desired biological activities. Additionally, it may also have uses in the field of materials science, specifically in the production of specialty polymers or coatings. The presence of the amino and fluoro groups in its structure makes Benzenemethanol, 3-amino-4-fluoro- (9CI) a valuable and versatile starting material for the preparation of diverse chemical compounds.

Upstream product

• 2365-85-7 3-amino-4-fluorobenzoic acid 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 

Downstream Products

• 227609-87-2 (4-fluoro-3-iodophenyl)methanol 
• 1051899-70-7 (3-(2-chloropyrimidin-4-ylamino)-4-fluorophenyl)methanol 
• 227609-71-4 9-(4-Fluoro-3-iodophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one,1,1-dioxide 
• 227609-88-3 4-fluoro-3-iodobenzaldehyde 

Relevant articles and documents

Cyclization of substitued 2-(2-fluorophenylazo)azines to azino[1, 2-c]benzo[d][1, 2, 4]triazinium derivatives

Light-induced cyclization of several substituted 2-(2-fluorophenylazo) azines in the presence of Ca2+ ions to the corresponding triazinium derivatives is investigated experimentally and computationally. The azo derivatives of 4-methylpyridine 4 undergo facile cyclization to the corresponding triazinium 1, and the rate of cyclization increases with increasing number of fluorine atoms at the benzene ring. No triazinium ions were obtained from azo derivatives of 4-cyanopyridine, pyrazine and pyrimidine, presumably due to their instability under the reaction conditions. The experimental results and mechanism are discussed with the aid of DFT computational results.

Asymmetric synthesis of 3-azide-4-fluoro-L-phenylalanine

The asymmetric synthesis of N-Fmoc-protected 3-azide-4-fluoro-L-phenylalanine as a photoactive phenylalanine analog has been achieved by Sch?llkopf's alkylation.

KINASE INHIBITORS

Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract