227626-62-2Relevant articles and documents
Oxadiazolone bioisosteres of pregabalin and gabapentin
Wustrow, David J.,Belliotti, Thomas R.,Capiris, Thomas,Kneen, Clare O.,Bryans, Justin S.,Field, Mark J.,Williams, Dic,El-Kattan, Ayman,Buchholz, Lisa,Kinsora, Jack J.,Lotarski, Susan M.,Vartanian, Mark G.,Taylor, Charles P.,Donevan, Sean D.,Thorpe, Andrew J.,Schwarz, Jacob B.
scheme or table, p. 247 - 250 (2009/05/26)
A series of oxadiazolone bioisosteres of pregabalin 1 and gabapentin 2 were prepared, and several were found to exhibit similar potency for the α2-δ subunit of voltage-gated calcium channels. Oxadiazolone 9 derived from 2 achieved low brain upt