22763-69-5

Basic information

• Product Name: 1-(2-PYRROLIDINOETHYL)PIPERAZINE
• Synonyms: RARECHEM AH CK 0196;1-(2-PYRROLIDINOETHYL)PIPERAZINE;1-[2-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE;1-[2-(1-PYRROLIDINO)ETHYL]PIPERAZINE;Pyrrolidinoethylpiperazine;1-(2-PYRROLIDINOETHYL)PIPERAZINE ~97%;Piperazine, 1-[2-(1-pyrrolidinyl)ethyl]- (8CI,9CI);1-[2-(1-Pyrrolidino)ethyl]piperazine 97%
• CAS NO: 22763-69-5
• Molecular Formula: C₁₀H₂₁N₃
• Molecular Weight: 183.29
• Product Categories: PIPERIDINE
• Mol File: 22763-69-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 77 °C
• Flash Point: 121.1 °C
• Appearance: /
• Density: 0.98 g/cm³
• Vapor Pressure: 0.00753mmHg at 25°C
• PKA: 9.19±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-(2-PYRROLIDINOETHYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-PYRROLIDINOETHYL)PIPERAZINE(22763-69-5)
• EPA Substance Registry System: 1-(2-PYRROLIDINOETHYL)PIPERAZINE(22763-69-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38-34
• Safety Statements: 26-36-39-45-36/37/39
• RIDADR: 2735
• HazardClass: 8
• Hazardous Substances Data: 22763-69-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

1-[2-(1-Pyrrolidinyl)ethyl]piperazine is an important raw material and intermediate used in pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C10H21N3/c1-2-6-12(5-1)9-10-13-7-3-11-4-8-13/h11H,1-10H2/p+3

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 7250-67-1 1-(2-chloroethyl)pyrrolidine hydrochloride 
• 77279-24-4 tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate 
• 208167-83-3 tert-butyl 4-(2-chloroethyl)tetrahydro-1(2H)-pyrazinecarboxylate 
• 1453097-93-2 tert-butyl 4-(2-(pyrrolidine-1-yl)ethyl)piperazine-1-carboxylate 

Downstream Products

• 939977-51-2 cyclopropanecarboxylic acid {5-(2,4-dichlorobenzylamino)-3-[4-(2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-[1,2,4]triazin-6-ylmethyl}-amide 
• 939977-52-3 5-(2,4-dichlorobenzylamino)-3-[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]-[1,2,4]triazine-6-carboxylic acid ethyl ester 
• 1032611-69-0 4-[2-(2,4-dichlorophenoxy)phenylsulfamoyl]-N-{2-oxo-2-[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]ethyl}benzamide 
• 444661-98-7 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-{[4-(2-pyrrolidin-1-ylethyl) piperazin-1-yl]sulfonyl}-3,4-dihydroquinazolin-2(1H)-one 

Relevant articles and documents

3-PHENYLSULPHONYL-QUINOLINE DERIVATIVES AS AGENTS FOR TREATING PATHOGENIC BLOOD VESSELS DISORDERS

The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.

Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents

Two series of novel 2-substituted 5,7-dihydroxyanthra[2,1-d]thiazole-6,11- dione derivatives from natural rhein were designed, synthesized and evaluated for their antitumour activities against human cancer cell lines A549 and HeLa in vitro.