22765-58-8Relevant academic research and scientific papers
A two-stage, three-stage aromatic amide compound synthesis method
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Paragraph 0041-0043, (2017/10/06)
The invention provides a synthetic method for forming binary and ternary aryl amide compounds by virtue of direct methyl functionalization. The method comprises the following steps: by taking a 2-methyl-N-heterocyclic aromatic hydrocarbon and an amine sou
Copper catalysed direct amidation of methyl groups with N-H bonds
Huang, Yao,Chen, Tieqiao,Li, Qiang,Zhou, Yongbo,Yin, Shuang-Feng
, p. 7289 - 7293 (2015/07/01)
An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.
Reaction of N-fluoropyridinium fluoride with isonitriles: A convenient route to picolinamides
Kiselyov, Alexander S.
, p. 2279 - 2282 (2007/10/03)
Reaction of N-fluoropyridinium fluoride generated in situ with a series of isonitriles led to the formation of the corresponding picolinamides in good yields. A similar reaction sequence for quinoline yielded the respective derivatives of 2-quinoline carboxylic acid. The proposed reaction mechanism involves the intermediate formation of a highly reactive carbene species.
