22772-26-5

Upstream product

• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 
• 106-48-9 4-chloro-phenol 
• 2089-33-0 4-methylacethophenone oxime 
• 71643-66-8 4-chloro-2-iodo phenol 
• 1338699-37-8 4-chloro-2-(p-tolylethynyl)phenol 
• 1620889-51-1 C₁₇H₁₅ClO₂ 
• 1620888-86-9 C₈H₈ClIO₂ 
• 5142-75-6 tri(p-tolyl)bismuth 
• 95186-48-4 4-chloro-2-<2',2'-dibromo ethenyl>-phenol 
• 766-97-2 4-n-methylphenylacetylene 
• 619-41-0 4-(bromoacetyl)toluene 
• 61548-21-8 4'-chlorophenoxyacetyl-4-methylbenzene 

Downstream Products

• 71943-40-3 3-{4-[4-(5-chloro-benzofuran-2-yl)-styryl]-phenyl}-1-phenyl-1H-pyrazole 
• 22798-47-6 5-chloro-2-{4-[2-(4-biphenylyl)vinyl]phenyl}benzofuran 
• 152862-78-7 2-(4-Bromomethyl-phenyl)-5-chloro-benzofuran 
• 71943-44-7 5-{4-[4-(5-chloro-benzofuran-2-yl)-styryl]-phenyl}-1,3-diphenyl-1H-pyrazole 
• 59151-45-0 4-{4-[4-(5-chloro-benzofuran-2-yl)-styryl]-phenyl}-2-phenyl-2H-[1,2,3]triazole 
• 65203-80-7 4-{4-[4-(5-chloro-benzofuran-2-yl)-styryl]-phenyl}-2,5-diphenyl-2H-[1,2,3]triazole 

Relevant academic research and scientific papers

A concise route to functionalized benzofurans directly from gem-dibromoalkenes and phenols

A tandem strategy for the construction of benzofuran motifs has been developed directly from gem-dibromoalkenes and phenols under palladium-catalyzed conditions. This flexible and novel methodology provides direct access to 2-aryl and 2-styryl benzofurans

Highly efficient heterogeneous synthesis of benzofurans under aqueous condition

Highly efficient organic reactions in water are important for designing environmental-friendly and low cost synthetic processes. Herein, we demonstrate an intermediate-in-water strategy for the heterogeneous synthesis of benzofurans in aqueous media. The cyclization reaction of 2-(phenylethynyl)phenol to 2-phenylbenzofuran cannot proceed in pure water. However, this reaction can be efficiently promoted by the formation of sparingly soluble intermediate in the presence of alkaline. Quantitative conversion of a variety of substrates to benzofuran derivatives has been achieved in the absence of noble metal catalyst. Other remarkable features including easy-isolation and purification of product, along with wide range of functional group tolerance render the methodology promising in the realm of green-synthesis.

One-Pot preparation of 2-arylbenzofurans from oximes with diaryliodonium triflate

A variety of 2-arylbenzofurans were obtained in good yields by the O-arylation of oximes with diaryliodonium triflates, followed by the treatment with HCl in dioxane under warming conditions through the [3,3]-sigmatropic reaction. The present reaction is one-pot transition metal-free method for the preparation of various 2-arylbenzofurans from oximes, which are easily available from the reaction of alkyl aryl ketones with hydroxylamine.

Pd-catalyzed tandem chemoselective synthesis of 2-arylbenzofurans using threefold arylating triarylbismuth reagents

A tandem chemoselective synthesis of 2-arylbenzofurans was accomplished from o-hydroxy-gem-(dibromovinyl)benzenes and BiAr3 reagents under palladium-catalyzed conditions. This unique and synthetically valuable strategy proceeds through three consecutive coupling reactions involving triarylbismuth reagents and provides 2-arylbenzofuran products in high yields. A tandem chemoselective synthesis of 2-arylbenzofurans was accomplished from o-hydroxy-gem-(dibromovinyl)benzenes and BiAr3 reagents under palladium-catalyzed conditions. This unique and synthetically valuable strategy proceeds through three consecutive coupling reactions involving triarylbismuth reagents and provides 2-arylbenzofuran products in high yields. Copyright

Domino synthesis of 2-arylbenzo[b]furans by copper(II)-catalyzed coupling of o-iodophenols and aryl acetylenes

A wide range of 2-arylbenzo[b]furans are synthesized through domino intermolecular C(aryl)-C(alkynyl) bond formation followed by intramolecular C(alkynyl)-O bond forming cyclization via copper(II)-catalyzed coupling of o-iodophenols and aryl terminal acetylenes. This method requires neither expensive palladium catalyst nor oxophilic phosphine ligands, can tolerate different functional groups. The methodology is successfully utilized in formal synthesis of β-amyloid aggregation inhibitor 5-chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-methoxyphenyl) benzofuran.

Synthesis and calcium antagonistic activity of a series of diethyl benzofuryl, benzothienyl and benzogammapyronyl benzylphosphonates

In this work we present about 15 original heterocyclic diethyl benzylphosphonate analogues of fostedil, in which we have varied the nature of the heterocycle, the substituents or the phosphonic group, or even the position of this latter.Three diethyl 4-(2

Stilbene optical brighteners and compositions brightened therewith

Benzofurans, benzothiophenes, indoles, naphthofurans and benzofuranobenzofurans which are substituted by 4-vinylphenyl groups wherein the 2-position of the vinyl is substituted by a monovalent aromatic radical having one to three aromatic rings are optica