22774-64-7

Upstream product

• 106-49-0 p-toluidine 
• 106-96-7 propargyl bromide 
• 81634-47-1 N-<3-(trimethylsilyl)-2-propynylidene>-p-toluidine 
• 34646-08-7 3-Chlor-phenylsulfonsaeure-propargylester 
• 20569-03-3 propargyl m-nitrobenzenesulphonate 
• 34646-10-1 propargyl p-nitrobenzenesulphonate 
• 624-65-7 2-propynyl chloride 
• 81634-54-0 N-<3-(trimethylsilyl)-2-propynyl>-p-toluidine 
• 5720-05-8 4-methylphenylboronic acid 
• 1220042-37-4 C₁₃H₁₃NO₂ 
• 16156-58-4 prop-2-yn-1-ol methanesulfonate 
• 6165-76-0 propargyl p-toluenesulfonate 
• 6165-75-9 propargyl benzenesulfonate 
• 659-86-9 propargyl iodide 

Downstream Products

• 114382-10-4 1-[(4-methylphenyl)amino]propan-2-one 
• 123533-76-6 N-p-tolyl-N-(2-phenylsulphinylprop-2-enyl)amine 
• 88320-36-9 2,5-dihydro-1-(4-methylphenyl)-1H-pyrrole 
• 53498-57-0 4-chloro-5-methyl-3-oxo-3H-isoxazole-2-carboxylic acid 4-methyl-N-prop-2-ynyl-anilide 
• 1229444-82-9 C₁₉H₂₂F₃NO 
• 1229444-86-3 C₁₇H₁₉NO₃ 
• 1229444-81-8 C₁₈H₂₀F₃NO 
• 1229444-84-1 C₁₅H₁₄Cl₃NO 
• 1229444-78-3 C₁₅H₁₄F₃NO 
• 1229444-79-4 C₁₆H₁₆F₃NO 
• 1229444-80-7 C₁₇H₁₈F₃NO 
• 1220042-37-4 C₁₃H₁₃NO₂ 
• 1220042-38-5 C₁₈H₁₅NO₂ 
• 1234345-30-2 C₁₇H₂₇N₄O₄P 

Relevant academic research and scientific papers

Compound of dipyrrolopyridine structure Preparation method and medical application

The invention discloses a compound with a dipyrrolo-pyridine structure as well as a preparation method and medical application thereof. The compound provided by the invention has obvious inhibitory activity on JAK family proteins, is an effective JAK inhibitor, and has the prospect of being developed into drugs for inhibiting JAK and further treating diseases.

One-pot, two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazoles

A facile, one-pot two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazole derivatives has been developed. The protocol employs an N-allylation of N-propargylated amines with 2,3-dibromopropene in the presence of K2CO3 in DMSO and a CuI-catalyzed [3 + 2] cycloaddition reaction of the synthetic N-(2-bromoallyl)-N-propargyl amines with sodium azide sequentially. Such a method provides methylene-substituted 1,2,3-triazole fused piperazines with some advantages such as simple operation, high efficiency and good product yield (80–91%) through readily available starting materials.

Synthesis and biological evaluation of coumarin-linked 4-anilinomethyl-1,2,3-triazoles as potent inhibitors of carbonic anhydrases ix and xiii involved in tumorigenesis

A series of coumarin-linked 4-anilinomethyl-1,2,3-triazoles (6a–t) was synthesized via a molecular hybridization approach, through carbon C-6 of the coumarin moiety. The synthesized compounds were evaluated for their inhibition of carbonic anhydrase (CA)

Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds

A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C-C bonds were formed in one pot.

New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo

Abstract: In order to discover novel anti-inflammatory agents, three series of compounds obtained by appending 1,2,3-triazole moieties on ursolic acid were designed and synthesized. All compounds have been screened for their anti-inflammatory activity by using an ear edema model. The potent anti-inflammatory compound was subjected to in vitro cyclooxygenase COX-1/COX-2 inhibition assays. In general, the derivatives were found to be potent anti-inflammatory activity. Especially, the compound 11b exhibited the strongest activity of all of the compounds prepared, with 82.81% inhibition after intraperitoneal administration, which was better than celecoxib as a positive control. Molecular docking results unclose the rationale for the interaction of the compound 11b with COX-2 enzyme. Further studies revealed that compound 11b exhibited effective COX-2 inhibitory activity, with half-maximal inhibitor concentration (IC50) value of 1.16?μM and selectivity index (SI = 64.66) value close to that of celecoxib (IC50 = 0.93?μM, SI = 65.47). Taken together, these results could suggest a promising chemotype for development of new COX-2-targeting anti-inflammatory agent. Graphic abstract: [Figure not available: see fulltext.]

Stereoselective Synthesis of Hexahydroimidazo[1,2- a]quinolines via SN2-Type Ring-Opening Hydroarylation-Hydroamination Cascade Cyclization of Activated Aziridines with N-Propargylanilines

A novel synthetic approach for the construction of 1,2,3,3a,4,5-hexahydroimidazo[1,2-a]quinolines in good yields (up to 75%) with excellent stereoselectivity (dr up to 94:6, ee up to >99%) under one-pot domino ring-opening cyclization (DROC) conditions ha

Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N -propargylanilines with diverse carbon pronucleophiles: Facile access to functionalized tetrahydroquinolines

Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with two types of carbon pronucleophiles (nitromethane as a sp3 carbon pronucleophile and phenylacetylenes as sp carbon pronucleophiles) proceeded to give the 2-substituted tetrahydroquinolines in good yields with 100percent atomic utilization without any additional external oxidants.

Facile, catalyst-free cascade synthesis of sulfonyl guanidines: Via carbodiimide coupling with amines

An expeditious catalyst-free cascade coupling of N,N-dibromoarylsulfonamides with isonitriles and amines via carbodiimide intermediates has been developed. The protocol represents an elegant pathway for sulfonyl guanidines at room temperature within a short time with high yields and wide substrate scope. The carbodiimide intermediate could also be isolated in an appreciable yield.

Synthesis and Activity of 1,2,3-Triazole Aminopyrimidines against Cyanobacteria as PDHc-E1 Competitive Inhibitors

Cyanobacteria harmful algal blooms are of global concern, but all currently available algicides in the market are nonselective and have potential side effects on nontarget species. In the present work, two series of compounds (4 and 6) comprising 16 novel

Hypervalent iodine compound containing heterocyclic ring as well as preparation method and application thereof

The invention discloses a hypervalent iodine compound containing a heterocyclic ring as well as a preparation method and application thereof. A structure of the compound is shown as a formula (I): theformula (I) is shown in the description, wherein R is selected from hydrogen, halogen, alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, nitryl, cyano, hydroxyl or -COOR'; R' is alkyl or halogenated alkyl; and Het is substituted or non-substituted 1,4-benzopyranone, substituted or non-substituted quinolone, substituted or non-substituted isoquinoline, substituted or non-substituted thiobenzopyranone, substituted or non-substituted coumarin and substituted or non-substituted oxepin. The compound disclosed by the invention is novel in structure and is the hypervalent iodine compound containing the heterocyclic ring; the hypervalent iodine compound is stable in structure and simple in preparation method; and meanwhile, the hypervalent iodine compound has a very good inhibition effect onML-1 and MOLM-13 cells and has an extremely great application prospect on prevention and/or treatment effect on leukemia.