227754-53-2

Basic information

• Product Name: (7R)-7-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indole-6,8(7H,10H)-dione
• CAS NO: 227754-53-2
• Molecular Formula: C₂₀H₁₇NO₃
• Molecular Weight: 319.3539
• Mol File: 227754-53-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 508.5°C at 760 mmHg
• Flash Point: 261.3°C
• Density: 1.36g/cm³
• Vapor Pressure: 3.67E-11mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: (7R)-7-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indole-6,8(7H,10H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (7R)-7-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indole-6,8(7H,10H)-dione(227754-53-2)
• EPA Substance Registry System: (7R)-7-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indole-6,8(7H,10H)-dione(227754-53-2)

Safety Data

• Hazardous Substances Data: 227754-53-2(Hazardous Substances Data)

Upstream product

• 1640-39-7 2,3,3-trimethylindoleniune 
• 59-88-1 phenylhydrazine hydrochloride 
• 465540-86-7 10,10-dimethyl-7-nitro-7-phenyl-10H-pyrido[1,2-a]indole-6,8(7H)-dione 
• 274691-31-5 8-hydroxy-10,10-dimethyl-7-phenyl-10H-pyrido[1,2-a]indol-6-one 
• 563-80-4 3-methyl-butan-2-one 

Relevant articles and documents

Synthesis and reactions of 10,10-dimethyl-10H-pyrido[1,2-a]indol-6-ones

Cyclocondensation of 2,3,3-trimethyl-3H-indoles 2 with malonates 3 gives 8-hydroxy-10,10-dimethyl-10H-pyrido[1,2-alindol-6-ones 4, which were halogenated in position 7, 8 and 9 with sulfuryl chloride, bromine or phosphoroxychloride to give the corresponding halo-10,10-dimethyl-10H-pyrido[1,2-a]indoles 5, 6, 7 and 8. Amination affords the 8-amino-10,10-dimethyl-10H-pyrido[1,2-a]indol-6-one 9. Nitration gives either the 10,10-dimethyl-7-nitro-10H-pyrido[1,2-a]indoles 10 or 10,10-dimethyl-7-hydroxy-10H-pyrido[1,2-a]indoles 11, depending on the conditions.