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CYCLO(-PRO-THR), also known as a diketopiperazine cyclodipeptide, is a compound that induces a blood-like, metallic bitter taste sensation. It is derived from roasted cocoa nibs and has gained attention for its unique taste profile.

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  • 227777-31-3 Structure
  • Basic information

    1. Product Name: CYCLO(-PRO-THR)
    2. Synonyms: CYCLO(-PRO-THR)
    3. CAS NO:227777-31-3
    4. Molecular Formula: C9H14N2O3
    5. Molecular Weight: 198.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 227777-31-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -15°C
    8. Solubility: N/A
    9. CAS DataBase Reference: CYCLO(-PRO-THR)(CAS DataBase Reference)
    10. NIST Chemistry Reference: CYCLO(-PRO-THR)(227777-31-3)
    11. EPA Substance Registry System: CYCLO(-PRO-THR)(227777-31-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 227777-31-3(Hazardous Substances Data)

227777-31-3 Usage

Uses

Used in Food Industry:
CYCLO(-PRO-THR) is used as a flavor enhancer for its ability to induce a blood-like, metallic bitter taste sensation. This application is particularly relevant in the development of novel flavors and taste experiences in the food and beverage sector.
Used in Pharmaceutical Industry:
CYCLO(-PRO-THR) is used as a research compound for understanding the molecular mechanisms behind taste sensations, specifically the blood-like, metallic bitter taste. This knowledge can be applied to develop new drugs or therapies targeting taste-related conditions or to create taste-masking agents for medications with unpleasant tastes.
Used in Cosmetic Industry:
CYCLO(-PRO-THR) may be used as an ingredient in the development of oral care products, such as mouthwashes or toothpaste, to provide a unique taste sensation or to mask unpleasant flavors. Its application in this industry could lead to innovative oral care products with enhanced sensory experiences for consumers.

Check Digit Verification of cas no

The CAS Registry Mumber 227777-31-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,7,7,7 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 227777-31:
(8*2)+(7*2)+(6*7)+(5*7)+(4*7)+(3*7)+(2*3)+(1*1)=163
163 % 10 = 3
So 227777-31-3 is a valid CAS Registry Number.

227777-31-3Downstream Products

227777-31-3Relevant articles and documents

AGRICULTURAL CHEMICAL CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT

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Paragraph 0033, (2013/06/05)

Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient.

An efficient green synthesis of proline-based cyclic dipeptides under water-mediated catalyst-free conditions

Thajudeen, Habeebullah,Park, Kyungseok,Moon, Surk-Sik,Hong, In Seok

scheme or table, p. 1303 - 1305 (2010/04/29)

l-Proline-based cyclic dipeptides were synthesized from N-Boc-protected dipeptide methyl esters under catalyst-free condition using water as a solvent. One-pot deprotection and cyclization have been used as the key steps, providing an efficient and environmentally friendly approach. Clean reaction conditions, easy isolation, and good yields of cyclic dipeptides are the salient features of the proposed methodology.

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