22780-71-8

Basic information

• Product Name: 7-CYANO-BENZO[B]THIOPHENE
• Synonyms: 1-benzothiophene-7-carbonitrile;7-CYANO-BENZO[B]THIOPHENE;Benzo[b]thiophene-7-carbonitrile;Benzo[b]thiophene-7-carbonitrile 97%;7-Cyano-1-benzothiophene;Benzothiophene-7-carbonitrile
• CAS NO: 22780-71-8
• Molecular Formula: C9H5NS
• Molecular Weight: 159.2077
• Mol File: 22780-71-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 67.5 °C
• Boiling Point: 312.7 °C at 760 mmHg
• Flash Point: 142.9 °C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.000522mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 7-CYANO-BENZO[B]THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CYANO-BENZO[B]THIOPHENE(22780-71-8)
• EPA Substance Registry System: 7-CYANO-BENZO[B]THIOPHENE(22780-71-8)

Safety Data

• Hazardous Substances Data: 22780-71-8(Hazardous Substances Data)

Usage

General Description

7-Cyano-Benzo[B]thiophene is an organic compound and falls under the category of simple aromatic compounds called thiophenes, specifically a derivative of benzo[b]thiophene. As the name indicates, this compound includes a cyano group (-CN), a benzo group, and a thiophene group, and they altogether form a complex structure. It appears as an off-white to beige crystalline powder at room temperature. As a chemical with potentially hazardous properties, it is intended to be handled with care in industrial and laboratory environments. It’s often used in the synthesis of other complex compounds and sometimes as an intermediate in chemical reactions. Its exact properties including toxicity, reactivity, and environmental impact can vary depending on specific conditions or the presence of other chemicals.

InChI:InChI=1/C9H5NS/c10-6-8-3-1-2-7-4-5-11-9(7)8/h1-5H

Upstream product

• 1423-61-6 7-bromobenzo(b)thiophene 
• 557-21-1 dicyanozinc 

Downstream Products

• 1119899-37-4 7-cyanobenzo[b]thiophen-2-yl-2-boronic acid 
• 10134-98-2 benzothiophen-7-carboxic acid 

Relevant articles and documents

NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS

The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases, cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.

PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS

Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.