227805-74-5

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 104-63-2 N-Benzylethanolamine 

Downstream Products

• 956434-18-7 N-benzyl-N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-chloronicotinamide 
• 1403381-78-1 C₂₃H₂₈BrFN₂O₂Si 
• 1403380-96-0 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid 
• 1403381-87-2 methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate 
• 1403381-86-1 methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-(tert-butoxy)acetate 
• 1403381-85-0 methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate 
• 1403381-84-9 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 1403381-82-7 4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepine-7-carbaldehyde 
• 1403381-79-2 N-benzyl-2-bromo-3-cyano-6-fluoro-N-(2-hydroxyethyl)benzamide 

Relevant academic research and scientific papers

Fluorous Peptide Nucleic Acids: PNA Analogues with Fluorine in Backbone (γ-CF2-apg-PNA) Enhance Cellular Uptake

Fluorous PNA analogues possessing fluorine as inherent part of aminopropylglycine (apg) backbone (γ-CF2-apg PNA) have been synthesized and evaluated for biophysical and cell penetrating properties. These form duplexes of higher thermal stability with cRNA than cDNA, although destabilized compared to duplexes of standard aeg-PNA. Cellular uptake of the fluorinated γ-CF2-apg PNAs in NIH 3T3 and HeLa cells was 2-3-fold higher compared to that of nonfluorinated apg PNA, with NIH 3T3 cells showing better permeability compared to HeLa cells. The backbone fluorinated PNAs, which are first in this class, when combined with other chemical modifications may have potential for future PNA-based antisense agents.

Catalytic Enantioselective Synthesis of Tetrahydocarbazoles and Exocyclic Pictet-Spengler-Type Reactions

A synthetic strategy for the synthesis of chiral tetrahydrocarbazoles (THCAs) has been developed. The strategy relies on two types of 6-exo-trig cyclization of 3-substituted indole substrates. Enantioselective domino Friedel-Crafts-type reactions leading to THCAs can be catalyzed by chiral phosphoric acid derivatives (with up to >99% ee), and the first examples of exocyclic Pictet-Spengler reactions to form THCAs are reported.

SELECTIVE HDAC6 INHIBITORS

The present invention provides hydroxamic acids of the formula described herein, that have activity toward inhibiting histone deacetylases, and in particular HDAC6. Also contemplated are pharmaceutical compositions and methods of use of an effective amount of the hydroxamic acid compounds provided, for treating a disease in a subject. In certain embodiments, the subject is afflicted with cancer, neurodegenerative disease, or HIV infection.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES

Compounds of formula (I), wherein R1, R4, HET-1 and HET-2 are as described in the specification, and their salts and pro-drugs, are activators of glucokinase (GLK) and are thereby useful in the treatment of, for example, type 2 diabetes. Processes for preparing compounds of formula (I) are also described.