Benzenemethanamine, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-

Base Information

Chemical Name:Benzenemethanamine, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-
CAS No.:227805-74-5
Molecular Formula:C15H27NOSi
Molecular Weight:265.471
Hs Code.:
Mol file:227805-74-5.mol

Synonyms:N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethylamine;benzyl({2-[(tert-butyldimethylsilyl)oxy]ethyl})amine;N-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}ethanamine;2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-N-(phenylmethyl)ethanamine;

Suppliers and Price of Benzenemethanamine, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Benzenemethanamine, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-

Chemical Property:

PSA：21.26000
LogP:4.18890

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzenemethanamine, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-

There total 2 articles about Benzenemethanamine, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 104-63-2
N-Benzylethanolamine

: 227805-74-5
N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethan-1-amine

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 227805-74-5
N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethan-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 12 h / 20 °C

2: triethylamine / acetonitrile / 12 h / 20 °C

With 1H-imidazole; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/acs.joc.5b01614

Reference yield: 99.0%

: 227805-74-5
N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethan-1-amine

: 393-53-3
3-fluoroisonicotinic acid

: 956434-22-3
N-benzyl-N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-3-fluoroisonicotinamide

Guidance literature:: 3-fluoroisonicotinic acid; With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 110 ℃; for 2h;

N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethan-1-amine; With triethylamine; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;