227809-77-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(quinolin-6-yl)ethanol is used as a synthetic intermediate for the development of various drugs, leveraging its unique chemical structure to contribute to the creation of novel medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(quinolin-6-yl)ethanol serves as a building block in the synthesis of pesticides, potentially enhancing crop protection and yield through its incorporation into new formulations.
Used in Therapeutic Applications:
2-(quinolin-6-yl)ethanol is studied for its potential therapeutic effects, particularly in the treatment of conditions such as cancer and neurodegenerative diseases, due to its interaction with biological targets and pathways implicated in these conditions.
Used in Antioxidant-based Skincare Products:
Capitalizing on its antioxidant properties, 2-(quinolin-6-yl)ethanol is considered for use in skincare products to protect the skin from oxidative stress and potentially reduce signs of aging or environmental damage.
The diverse applications of 2-(quinolin-6-yl)ethanol underscore its versatility and the ongoing research and development efforts aimed at harnessing its full potential across different industries.

Upstream product

• 5622-34-4 6-quinoline acetic acid 
• 5622-36-6 methyl 2-(quinolin-6-yl)acetate 

Downstream Products

• 1051316-46-1 6-(2-bromoethyl)quinoline 

Relevant academic research and scientific papers

QUINSTATIN COMPOUNDS

The present disclosure relates to Quinstatin compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or pharmaceutical compositions.

Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors

Discovery of the exceptionally powerful anticancer drug dolastatin 10 (1), contained in the sea hare Dolabella auricularia, opened a new frontier needed for improving human cancer treatment. Subsequently, major advances have been achieved based on results of structurally modifying this unusual natural peptide while maintaining the remarkable anticancer activity necessary for preparation of successful monoclonal antibody drug conjugates (ADC). Among the first several hundred SAR products based on dolastatin 10 our group synthesized and termed auristatins was auristatin E (2a). An anticancer activity-equivalent, desmethylaurisatin E (2b), linked to a CD30 monoclonal antibody is the very successful anticancer drug Adcetris, now approved for use in 65 countries. In the present investigation, we discovered a new subset of auristatins designated quinstatins derived from dolastatin 10 by replacing the C-terminal Doe unit with a carefully designed quinoline, which led to low or subnanomolar levels of cancer cell growth inhibition required for construction of chemically unique ADC drugs. The synthesis of quinstatins 2-8 is presented along with their cancer cell line biological data.

FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS

The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a disease or disorder, such as a proliferative disease (preferably cancer), using compounds of the invention.

NITROGEN-CONTAINING HETEROCYCLYL KETONES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.