22788-19-8

Usage

Uses

Used in Pharmaceutical Industry:
Propylene Glycol Dilaurate is used as a surfactant for enhancing the stability and bioavailability of drugs. Its ability to reduce surface tension between oil and water phases allows for better dispersion and absorption of active pharmaceutical ingredients.
Used in Cosmetic Industry:
Propylene Glycol Dilaurate is used as an excipient in the formulation of cosmetics, particularly in creams, lotions, and ointments. It acts as an emollient, providing a smooth and soft texture to the skin, and also serves as a solubilizer for various cosmetic ingredients, ensuring their uniform distribution within the product.
Used in Lipid-based Drug Delivery Systems:
Propylene Glycol Dilaurate is used as a key component in the synthesis of lipid-based drug delivery systems. Its amphiphilic nature enables the formation of lipid nanoparticles or liposomes, which can encapsulate and protect drug molecules, improving their targeted delivery and controlled release.

InChI:InChI=1/C27H52O4/c1-4-6-8-10-12-14-16-18-20-22-26(28)30-24-25(3)31-27(29)23-21-19-17-15-13-11-9-7-5-2/h25H,4-24H2,1-3H3

Upstream product

• 112-16-3 n-dodecanoyl chloride 
• 57-55-6 propylene glycol 
• 143-07-7 lauric acid 
• 645-66-9 lauric anhydride 
• 75-56-9 methyloxirane 

Downstream Products

• 143-07-7 lauric acid 
• 10546-44-8 1,2-bis-sulfooxy-propane 

Relevant academic research and scientific papers

Production of propylene glycol fatty acid monoesters by lipase-catalyzed reactions in organic solvents

Fatty acid monoesters of propylene glycol (1,2-propanediol) are good water-in-oil emulsifiers. These esters were synthesized enzymatically to overcome the problems associated with chemical processes. A Pseudomonas lipase was added to reaction mixtures containing propylene glycol and various acyl donors (fatty acids, fatty acid ethyl esters, fatty acid anhydrides and triglycerides) in organic solvents, and the mixtures were shaken at 30 °C. The products were analyzed by gas chromatography. The yield of monoesters was affected by the acyl donors, organic solvents, temperature, water content, pH memory and reaction time. The anhydrous (lyophilized) enzyme and fatty acid anhydrides were best for monoester production. The optimum pH ranges were 4-5 and 8-10. The yields of propylene glycol monolaurate, monomyristate, monopalmitate, monostearate and monooleate with 50 mM fatty acid anhydrides as acyl donors were 97.2, 79.6, 83.7, 89.7 and 93.4 mM, respectively; those with 50 mM fatty acids as acyl donors were 37.3, 28.7, 28.7, 35.3 and 36.2 mM, respectively. The yields of propylene glycol monopalmitate, monostearate and monooleate with 50 mM triglycerides as acyl donors were 87.4, 65.1 and 83.2 mM, respectively.

Fat Hydrolysis and Esterification by a Lipase from Humicola lanuginosa

The hydrolysis and esterification by a thermostable lipase from Humicola lanuginosa No. 3 were investigated.Both reactions occurred readily at temperatures between 45-50 deg C.Esterification by the enzyme with glycerol was observed to be specific towards fatty acids with carbon numbers of C12-C18.Lauric acid esters with different alcohols such as primary alcohols, terpene alcohols, etc., were also synthesized readily.Esterification by the enzyme was adversely affected by the water content (optimum, ca. 7percent), however, the hydrolysis rate increased rapidly with increasing water content (optimum, ca. 60percent).The enzyme showed increased activity in organic solvent-aqueous reaction systems.Nevertheless, hydrolysis in complete organic phase reactions was found not to be feasible.Hydrolysis at a higher temperature (50 or 55 deg C) in a solvent free phase was almost the same as that in organic solvent-aqueous phase reactions.The components of glycerides varied considerably during hydrolysis, whereby esterification resulted in a higher quantity of mono- and diglycerides (about 40percent), compared to in the case of hydrolysis, for which the value was about 10-20percent.