227953-64-2Relevant academic research and scientific papers
New efficient nickel-catalyzed cross-coupling reaction between two Csp3 centers
Giovannini,Strudemann,Devasagayaraj,Dussin,Knochel
, p. 3544 - 3553 (2007/10/03)
The presence of a remote unsaturation (double bond, carbonyl group, cyano group) in an alkyl halide facilitates its cross-coupling reaction with various diorganozincs in the presence of Ni(acac)2 (7.5-10 mol % in THF/NMP mixtures). These results were used to develop a new general cross-coupling reaction between functionalized diorganozincs and alkyl iodides using m- or p-trifluoromethylstyrene as a reaction promotor and Ni(acac)2 as a catalyst (7.5-10 mol %; -35 °C, 5-10 h) leading to a broad range of polyfunctional cross-coupling products.
