22798-96-5Relevant articles and documents
Trifluoroacetylation and dehydration of 20-hydroxyecdysone acetonides. Synthesis of stachisterone B
Odinokov,Galyautdinov,Nedopekin,Khalilov
, p. 232 - 236 (2003)
Trifluoroacetylation of the 25(OH)-group with subsequent dehydration of the 14(OH)-group takes place in the reaction of 20-hydroxyecdysone 20,22-acetonide and 2,3:20,22-diacetonide with trifluoroacetic anhydride in the presence of pyridine. Dehydration of
Steroidal ligands and their use in gene switch modulation
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Page/Page column 46, (2016/02/15)
The present invention relates to steroidal ligands for use in nuclear receptor-based inducible gene expression systems. The invention further relates to methods of modulating the expression of genes of interest with a system containing one or more nuclear
Synthesis and structure-activity relationships of novel ecdysteroid dioxolanes as MDR modulators in cancer
Martins, Ana,Csabi, Jozsef,Balazs, Attila,Kitka, Diana,Amaral, Leonard,Molnar, Jozsef,Simon, Andras,Toth, Gabor,Hunyadi, Attila
, p. 15255 - 15275 (2014/01/17)
Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug resistance of a transfected murine leukemia cell line. In this paper, we present a structure-activity relationship study focused on the apolar dioxolane derivatives of 20-hydroxyecdysone. Semi-synthesis and bioactivity of a total of 32 ecdysteroids, including 20 new compounds, is presented, supplemented with their complete 1H- and 13C-NMR signal assignment.