2280-40-2

Basic information

• Product Name: Threoninamide
• Synonyms: L-Threoninamide
• CAS NO: 2280-40-2
• Molecular Formula: C₄H₁₀N₂O₂
• Molecular Weight: 0
• Mol File: 2280-40-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Threoninamide(CAS DataBase Reference)
• NIST Chemistry Reference: Threoninamide(2280-40-2)
• EPA Substance Registry System: Threoninamide(2280-40-2)

Safety Data

• Hazardous Substances Data: 2280-40-2(Hazardous Substances Data)

Upstream product

• 3373-59-9 (+/-)-threonine methyl ester hydrochloride 
• 3373-59-9 allo-Thr-OMe 

Downstream Products

• 118355-39-8 N-CBZ-L-Tyr-L-Thr-NH₂ 
• 632-20-2 D-Threonine 

Relevant articles and documents

Synthetic method for chiral alpha-aminoamide compounds

The invention provides a synthetic method for chiral alpha-aminoamide compounds, belongs to the technical field of organic synthetic methodology, and concretely relates to a synthetic method for chiral alpha-aminoamide compounds, wherein the method has a simple process, low costs and good economy. The method comprises the following steps: 1, performing ammonolysis: adding substituted chiral alpha-aminocarboxylate hydrochloride into concentrated ammonia water, performing stirring for 4-12h under a room temperature, wherein each 1mmol substituted chiral alpha-aminocarboxylate hydrochloride is corresponding to 2-8mL the concentrated ammonia water; 2, after a reaction is finished, performing distillation for removing ammonia water after the reaction to obtain crude products chiral alpha-aminoamide compounds; and 3, performing filtration on the obtained crude products chiral alpha-aminoamide compounds by adopting a manner of adding a solvent or performing purification on the obtained crude products chiral alpha-aminoamide compounds through a manner of column chromatography which uses ammonia water as a mobile phase to obtain the products chiral alpha-aminoamide compounds. Compared with the prior art, a large number of an ammonia gas for ammonolysis is not needed in the method, the process and post-treatment are simple, costs are low and reaction time is short.