228103-63-7Relevant academic research and scientific papers
Streamlined synthesis of the bippyphos family of ligands and cross-coupling applications
Withbroe, Gregory J.,Singer, Robert A.,Sieser, Janice E.
, p. 480 - 489 (2008)
We describe the efficient preparation of Bippyphos, 1. The key precursor to Bippyphos, 5, was prepared via a one-pot bromination of diketone 2 followed by alkylation with pyrazole and condensation with phenylhydrazine. Lithiation of 5 and trapping with ditert-butylchlorophosphine afforded Bippyphos, 1. Using this approach we have prepared several derivatives of Bippyphos to probe the structure and activity relationships of this family of phosphine ligands. We also demonstrate the utility of these ligands in Pdcatalyzed amination reactions and other cross-coupling reactions.
