228262-79-1

Upstream product

• 150-76-5 4-methoxy-phenol 
• 228262-78-0 (1S,2R)-2-((S)-2-Hydroxy-1-methyl-ethyl)-cyclopentanecarboxylic acid methyl ester 
• 228262-77-9 (1S,2R)-2-((S)-1-Methyl-2-oxo-ethyl)-cyclopentanecarboxylic acid methyl ester 

Downstream Products

• 228262-80-4 (1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentanecarboxylic acid methyl ester 
• 228262-85-9 {(1S,2R)-1-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-4-oxo-hex-2-enyl]-2-[(S)-2-(4-methoxy-phenoxy)-1-methyl-ethyl]-cyclopentyl}-carbamic acid benzyl ester 
• 228262-83-7 [(1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentyl]-carbamic acid benzyl ester 
• 228262-81-5 (1S,2R)-2-[(S)-2-(4-Methoxy-phenoxy)-1-methyl-ethyl]-1-(3-methyl-but-2-enyl)-cyclopentanecarboxylic acid 
• 228262-82-6 1-{(S)-2-[(1R,2S)-2-Isocyanato-2-(3-methyl-but-2-enyl)-cyclopentyl]-propoxy}-4-methoxy-benzene 

Relevant academic research and scientific papers

Synthesis of pinnaic acid; asymmetric construction of spirocyclic core

An asymmetric synthesis of the spirocyclic core of pinnaic acid, a cPLA2 inhibitor, is described. A key transformation in the sequence involves an asymmetric Michael-initiated ring closure.