22839-86-7Relevant academic research and scientific papers
Hexafluoroacetone as protection and activation reagent in amino acid and peptide chemistry regiospecific α-functionalization of aspartic acid
Burger, Klaus,Lange, Torsten,Rudolph, Martin
, p. 189 - 198 (2003)
A highly efficient method for regiospecific α-functionalization of aspartic acid is described. Key step is the synthesis of a N-protected and regioselectively α-carboxy-activated heterocyclic intermediate from aspartic acid and hexafluoroacetone. The new strategy offers i.a. a two step access to the sweetener Aspartame and to libraries of aspartame analogues.
