228405-26-3

Upstream product

• 75859-97-1 4-t-butyldimethylsilyloxy-2-butynal 
• 228405-25-2 [6-(t-butyldiphenyl-silyl)oxy]-2-oxohexylphosphonic acid dimethyl ester 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 14273-92-8 methyl 5-hydroxypentanoate 
• 86120-46-9 4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol 
• 179690-97-2 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 228405-27-4 10-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-6,7-dihydroxy-dec-8-yn-5-one 
• 228405-28-5 acetic acid 2-acetoxy-5-(tert-butyl-dimethyl-silanyloxy)-1-[5-(tert-butyl-diphenyl-silanyloxy)-pentanoyl]-pent-3-ynyl ester 

Relevant academic research and scientific papers

Synthetic study on naturally occurring acetylenic spiroacetal enol ethers: The first access to optically active 3,4-diacetoxy-2-formylmethylene- 1,6-dioxaspiro[4.5]decanes

Optically active 3,4-diacetoxy-2-formylmethylene-1,6- dioxaspiro[4.5]decanes have been synthesized from an acyclic keto-alcohol possessing an unsaturated aldehyde part via intramolecular conjugate addition. The C3- and C4-stereogenic centers were introduced via Sharpless asymmetric dihydroxylation of an acyclic conjugated ketone with modified AD- mix-α in high enantioselectivity (96% e.e.). This is the first access to optically active spiroacetal 2-enol ethers.