228419-04-3

Upstream product

• 363625-81-4 4-cyclohexyl-3-methyl-4-oxo-3-phenyl-1-butanol 
• 228419-06-5 2-phenyl-2-methyl-4-pentenoyl cyclohexane 
• 228419-03-2 1,1-diethoxy-3-phenyl-3-cyclohexanecarbonyl-butane 
• 228419-07-6 4-cyclohexyl-3-methyl-4-oxo-3-phenylbutyraldehyde dimethyl acetal 

Downstream Products

• 363625-82-5 E-1-(4'-cyclohexyl-3'-methyl-4'-oxo-3'-phenylbut-1-enyl)-4-(2-methoxyphenyl) piperazine 
• 228418-82-4 1-(4'-cyclohexyl-3'-methyl-4'-oxo-3'-phenylbutyl)-4-(2-methoxyphenyl) piperazine 
• 228418-97-1 3-cyclohexanecarbonyl-3-phenylpropionaldehyde 

Relevant academic research and scientific papers

Arylpiperazines having activity at the serotonin 1A receptor

A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

Piperidine derivatives as reuptake inhibitors

The present invention provides compounds of formula (I) and a method of inhibiting the reuptake of serotonin and antagonizing the serotonin receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula (I).

Piperidine derivatives as serotonine reuptake inhibitors

The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT1Areceptor and antagonizing the 5-HT2Areceptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.

Enantioselective process for preparing arylated lactones and derivatives

This invention provides a process for the arylation of lactones to form to chiral and achiral aryllactones having high enantioselectivity where applicable.

Pyrrolidine and pyrroline derivatives having effects on serotonin related systems

The present invention provides the compounds of the following formula (I): and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT1Areceptor and antagonizing the 5-HT2Areceptor which comprises administering to a subject in need of such treatment an effective amount of formula (I).

Arylpiperazines having activity at the serotonin 1A receptor

A series of aryl piperazine compounds of the formula: or the pharmaceutically acceptable salts thereof, are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1Areceptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.